BNIP3
BNIP3，全稱為BCL2/腺病毒E1B 19kDa相互作用蛋白3，常見別名有NIP3。它是細胞內(nèi)一種與生存死亡相關(guān)的蛋白，常參與細胞對低氧環(huán)境的適應(yīng)。當細胞處于缺氧狀態(tài)時，BNIP3的表達水平可能上升，通過和其他分子的相互作用，影響細胞的命運選擇，比如推動細胞死亡或啟動自噬過程。
在疾病領(lǐng)域，BNIP3與多種癌癥關(guān)系緊密。像肺癌、肝癌、乳腺癌等實體瘤中，它的表達異常常和腫瘤進展、耐藥性及患者預(yù)后相關(guān)。部分腫瘤里BNIP3的高表達能幫助腫瘤細胞耐受缺氧微環(huán)境，進而促進腫瘤生長和轉(zhuǎn)移。藥物研發(fā)方面，目前實驗室里有研究嘗試通過調(diào)控BNIP3的活性來提升癌癥治療效果，比如開發(fā)小分子調(diào)節(jié)劑或結(jié)合現(xiàn)有療法，但這些探索還處于早期階段，尚未進入臨床應(yīng)用。
熱銷產(chǎn)品
BNIP3 Recombinant Monoclonal Antibody (CSB-RA597344A0HU)
驗證數(shù)據(jù)
Flow cytometric analysis of BNIP3 expression in C2C12 cells using BNIP3 antibody. Green, isotype control; red, BNIP3.
Immunocytochemical staining of C2C12 cells with BNIP3 antibody. Nuclei were stained blue with DAPI; BNIP3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using BNIP3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with BNIP3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
BNIP3 Antibody (CSB-PA618642ESR1HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA618642ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618642ESR1HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA618642ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
BNIP3 Antibodies
BNIP3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA618642ESR1HU | BNIP3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA004979 | BNIP3 Antibody | Human | WB, ELISA |
| CSB-PA050118 | BNIP3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA093779 | BNIP3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA084239 | BNIP3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA552618A0HU | BNIP3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
| CSB-RA597344A0HU | BNIP3 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
BNIP3 Proteins
BNIP3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002766MO1 CSB-BP002766MO1 CSB-MP002766MO1 CSB-EP002766MO1-B |
Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002766MO | Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) | in vitro E.coli expression system |
| CSB-EP002766MO1 | Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), partial | E.coli |
| CSB-CF002766MO2 | Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), partial | in vitro E.coli expression system |
| CSB-MP002766MO | Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3)-VLPs | Mammalian cell |
BNIP3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP618642HU1 CSB-EP618642HU1 CSB-BP618642HU1 CSB-MP618642HU1 CSB-EP618642HU1-B |
Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF618642HU | Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) | in vitro E.coli expression system |
BNIP3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP656958BO1 CSB-EP656958BO1 CSB-BP656958BO1 CSB-MP656958BO1 CSB-EP656958BO1-B |
Recombinant Bovine BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF656958BO | Recombinant Bovine BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) | in vitro E.coli expression system |
