CACNA1C
CACNA1C，全稱為電壓門控L型鈣通道α1C亞基，常用別名是Cav1.2。它是細胞表面關鍵的通道蛋白，能引導鈣離子進入細胞，在多個器官系統中扮演重要角色：在心臟里，它幫助維持正常心跳節律與心肌收縮，保障心臟泵血功能；在神經系統中，它參與神經信號傳遞和突觸功能調節，和大腦信息處理緊密相關。
CACNA1C異常會引發多種疾病：部分心律失常（如長QT綜合征）患者，其結構或功能出現問題，導致心跳紊亂；精神分裂癥、雙相情感障礙等精神疾病中，也常觀察到它的表達或活性改變。藥物研發方面，經典鈣通道阻滯劑如硝苯地平，通過調節它來降低血壓、緩解心絞痛；目前還有研究針對它開發新型藥物，嘗試改善精神疾病癥狀或治療心血管疾病。
熱銷產品
CACNA1C Antibody (CSB-PA615724LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA615724LA01HU at dilution of 1:100
Immunofluorescence staining of Hela cells with CSB-PA615724LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
CACNA1C Antibodies
CACNA1C for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA145166 | CACNA1C Antibody | Human | ELISA,IHC |
| CSB-PA132003 | CACNA1C Antibody | Human | ELISA,IHC |
| CSB-PA195001 | CACNA1C Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA775374 | CACNA1C Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA615724LA01HU | CACNA1C Antibody | Human | ELISA, IHC, IF |
| CSB-PA615724LB01HU | CACNA1C Antibody, HRP conjugated | Human | ELISA |
| CSB-PA615724LC01HU | CACNA1C Antibody, FITC conjugated | Human | |
| CSB-PA615724LD01HU | CACNA1C Antibody, Biotin conjugated | Human | ELISA |
CACNA1C Proteins
CACNA1C Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004399RB CSB-EP004399RB CSB-BP004399RB CSB-MP004399RB CSB-EP004399RB-B |
Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CACNA1C Proteins for Cavia porcellus (Guinea pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004399GU1 CSB-EP004399GU1 CSB-BP004399GU1 CSB-MP004399GU1 CSB-EP004399GU1-B |
Recombinant Guinea pig Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004399GU | Recombinant Guinea pig Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), partial | in vitro E.coli expression system |
| CSB-MP004399GU | Recombinant Guinea pig Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)-VLPs | Mammalian cell |
CACNA1C Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004399CH1 CSB-EP004399CH1 CSB-BP004399CH1 CSB-MP004399CH1 CSB-EP004399CH1-B |
Recombinant Chicken Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004399CH | Recombinant Chicken Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) | in vitro E.coli expression system |
CACNA1C Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004399RA CSB-EP004399RA CSB-BP004399RA CSB-MP004399RA CSB-EP004399RA-B |
Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1C (Cacna1c), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CACNA1C Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP615724HU CSB-EP615724HU CSB-BP615724HU CSB-MP615724HU CSB-EP615724HU-B |
Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
