CBLIF
CBLIF，全稱為鈷胺素結合內因子，常見別名有 GIF、IF、INF、IFMH、TCN3，是胃黏膜壁細胞分泌的糖蛋白，主要在胃部合成并釋放至消化道內NCBI。它能特異性結合食物中的維生素 B12，保護其在胃酸環境中不被降解，并護送至回腸部位完成吸收，是人體獲取維生素 B12 的必需載體，對紅細胞成熟、神經功能維持至關重要。
CBLIF功能異常直接引發先天性內因子缺乏癥，導致維生素 B12 吸收障礙，誘發巨幼細胞性貧血、神經退化、認知障礙等癥狀。自身免疫損傷也會導致內因子缺乏，引發后天性惡性貧血。目前臨床以注射或高劑量口服維生素 B12 替代治療為主，重組 CBLIF 蛋白制劑與口服吸收增強型藥物正處于臨床前研發，有望為相關缺乏癥提供更便捷的干預方案。
熱銷產品
Recombinant Human Cobalamin binding intrinsic factor (CBLIF) (CSB-YP009417HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CBLIF Antibody (CSB-PA009417YA01HU)
驗證數據
Western blot
All lanes: CBLIF antibody at 2µg/ml + Mouse stomach tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46, 43 kDa
Observed band size: 46 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009417YA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA009417YA01HU at dilution of 1:100
CBLIF Antibodies
CBLIF for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA009417LA01HU | CBLIF Antibody | Human | ELISA, IHC |
| CSB-PA009417LD01HU | CBLIF Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA009417YA01HU | CBLIF Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA009417YD01HU | CBLIF Antibody, Biotin conjugated | Human | ELISA |
CBLIF Proteins
CBLIF Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP009417HU | Recombinant Human Cobalamin binding intrinsic factor (CBLIF) | Yeast |
