CCND2
CCND2，全稱為細胞周期蛋白D2（Cyclin D2），日常研究中常直接稱其為Cyclin D2，偶爾也用G1/S期特異性周期蛋白D2來指代。它是調控細胞生長分裂節奏的關鍵分子，能與周期蛋白依賴性激酶4/6結合，幫助細胞從靜止狀態進入DNA復制階段，維持細胞增殖的正常秩序。
CCND2活性受Wnt、PI3K等分子網絡的影響，一旦表達或功能異常，細胞可能不受控制地分裂，與非霍奇金淋巴瘤、乳腺癌、卵巢癌等多種癌癥相關——這些腫瘤中常可見CCND2過度表達，助推腫瘤生長。目前針對這類異常的治療已有進展，比如靶向周期蛋白依賴性激酶4/6的抑制劑，在攜帶CCND2異常的腫瘤患者中顯示出一定療效，為相關疾病治療提供了新方向。
熱銷產品
Recombinant Human G1/S-specific cyclin-D2 (CCND2), Biotinylated (CSB-EP004812HU-B)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCND2 Antibody (CSB-PA004812LA01HU)
驗證數據
Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue, Mouse kidney tissue
All lanes: CCND2 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 34, 25 kDa
Observed band size: 34 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA004812LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CCND2 Antibodies
CCND2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004812GA01HU | CCND2 Antibody | Human,Mouse,Rat | ELISA,IHC,IF |
| CSB-PA004812ESR2HU | CCND2 Antibody | Human, Mouse | ELISA, WB, IHC,IF |
| CSB-PA931919 | CCND2 (Ab-280) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA211813 | Phospho-CCND2 (Thr280) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA070181 | Phospho-CCND2 (T280) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA070182 | CCND2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA952756 | CCND2 Antibody | Human | ELISA,IHC |
| CSB-PA098232 | CCND2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA004812LA01HU | CCND2 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA004812LC01HU | CCND2 Antibody, FITC conjugated | Human | |
| CSB-PA004812LD01HU | CCND2 Antibody, Biotin conjugated | Human | ELISA |
CCND2 Proteins
CCND2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004812RA CSB-EP004812RA CSB-BP004812RA CSB-MP004812RA CSB-EP004812RA-B |
Recombinant Rat G1/S-specific cyclin-D2 (Ccnd2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004812MO CSB-EP004812MO CSB-BP004812MO CSB-MP004812MO CSB-EP004812MO-B |
Recombinant Mouse G1/S-specific cyclin-D2 (Ccnd2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004812HU CSB-BP004812HU CSB-MP004812HU |
Recombinant Human G1/S-specific cyclin-D2 (CCND2) | Yeast Baculovirus Mammalian cell |
| CSB-EP004812HU | Recombinant Human G1/S-specific cyclin-D2 (CCND2) | E.coli |
| CSB-EP004812HU-B | Recombinant Human G1/S-specific cyclin-D2 (CCND2), Biotinylated | E.coli |
| CSB-EP004812HUc7 | Recombinant Human G1/S-specific cyclin-D2 (CCND2) | E.coli |
CCND2 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004812CH CSB-EP004812CH CSB-BP004812CH CSB-MP004812CH CSB-EP004812CH-B |
Recombinant Chicken G1/S-specific cyclin-D2 (CCND2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND2 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004812XBE CSB-EP004812XBE CSB-BP004812XBE CSB-MP004812XBE CSB-EP004812XBE-B |
Recombinant Xenopus laevis G1/S-specific cyclin-D2 (ccnd2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND2 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP610365BO CSB-EP610365BO CSB-BP610365BO CSB-MP610365BO CSB-EP610365BO-B |
Recombinant Bovine G1/S-specific cyclin-D2 (CCND2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND2 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP855456PI CSB-EP855456PI CSB-BP855456PI CSB-MP855456PI CSB-EP855456PI-B |
Recombinant Pig G1/S-specific cyclin-D2 (CCND2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
