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CCR9

CCR9,全稱為C-C趨化因子受體9,也常被稱為CD199。它主要存在于某些T細胞表面,能與特定的信號分子結合,引導這些免疫細胞向腸道部位遷移,在腸道免疫防御和穩態維持中發揮關鍵作用。當CCR9功能失衡時,可能導致腸道免疫反應紊亂,與克羅恩病、潰瘍性結腸炎等慢性腸道炎癥疾病密切相關;部分胃腸道腫瘤細胞也會異常表達該蛋白,助力腫瘤細胞的遷移和擴散。目前針對CCR9的藥物研發聚焦于能阻斷其作用的拮抗劑,已有候選藥物進入臨床試驗階段,嘗試通過這種方式減輕腸道炎癥或抑制腫瘤進展,為相關疾病的治療提供新的方向。

熱銷產品

Recombinant Human C-C chemokine receptor type 9 (CCR9)-VLPs (Active) (CSB-MP004848HU)

驗證數據

CSB-MP004848HU

CSB-MP004848HU is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP004848HU

The purity of VLPs was greater than 95% as determined by HPLC-SEC.

CSB-MP004848HU

Measured by its binding ability in a functional ELISA. Immobilized Human CCR9 at 10μg/mL can bind Anti-CCR9 recombinant antibody (CSB-RA004848MA1HU),the EC50 is 31.67-36.83 ng/mL.The VLPs (CSB-MP3838) is negative control.

Recombinant Human C-C chemokine receptor type 9 (CCR9), partial (CSB-EP004848HU1)

驗證數據

CSB-EP004848HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCR9 Recombinant Monoclonal Antibody (CSB-RA004848MA1HU)

驗證數據

CSB-RA004848MA1HU

The Binding Activity of CCR9 with Anti-CCR9 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR9 at 10 μg/mL can bind Anti-CCR9 recombinant antibody (CSB-RA004848MA1HU). The EC50 is 31.67-36.83 ng/mL.The VLPs (CSB-MP3838) is negative control.

CSB-RA004848MA1HU

Untransfected MC38 cells (green line) and transfected Human CCR9 MC38 stable cells (red line) were stained with anti-CCR9 antibody (CSB-RA004848MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CCR9 Antibodies

CCR9 for Homo sapiens (Human)

CCR9 Proteins

CCR9 Proteins for Homo sapiens (Human)

CCR9 Proteins for Ovis aries (Sheep)

CCR9 Proteins for Mus musculus (Mouse)



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