CCS，全稱為銅伴侶蛋白 SOD1，常見(jiàn)別名有 SOD1 銅分子伴侶、CCS1、銅離子結(jié)合蛋白 CCS，是廣泛分布于細(xì)胞質(zhì)與細(xì)胞核內(nèi)的銅結(jié)合蛋白。它主要負(fù)責(zé)將銅離子轉(zhuǎn)運(yùn)并傳遞給超氧化物歧化酶 SOD1，幫助其完成成熟活化，同時(shí)參與細(xì)胞內(nèi)銅穩(wěn)態(tài)維持，清除活性氧自由基，保護(hù)細(xì)胞免受氧化應(yīng)激損傷，在神經(jīng)、肌肉等多種組織中均發(fā)揮重要生理功能。
CCS異常與多種疾病密切相關(guān)，其功能缺陷會(huì)導(dǎo)致 SOD1 活性下降，與肌萎縮側(cè)索硬化、阿爾茨海默病等神經(jīng)退行性疾病緊密關(guān)聯(lián)，也參與腫瘤細(xì)胞增殖與耐藥過(guò)程。目前相關(guān)研究聚焦于銅代謝調(diào)控與神經(jīng)保護(hù)，靶向 CCS 的小分子調(diào)節(jié)劑已進(jìn)入臨床前篩選，可通過(guò)調(diào)節(jié)銅轉(zhuǎn)運(yùn)改善氧化應(yīng)激損傷，為神經(jīng)退行性疾病及腫瘤的治療提供新的潛在靶點(diǎn)。

熱銷產(chǎn)品

CCS Antibody (CSB-PA004854LA01HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA004854LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.