CDK12
CDK12，全稱為周期蛋白依賴性激酶 12，常用別名細胞周期調控激酶 12。它是定位于細胞核內的重要調控蛋白，參與細胞周期有序運轉、基因組穩定性維護以及 DNA 損傷修復過程，保障正常細胞有序增殖分裂，對機體組織發育、細胞穩態維持具有不可替代的作用。
CDK12 突變失活及異常高表達與乳腺癌、卵巢癌、前列腺癌等高發惡性腫瘤密切相關，會造成基因組高度不穩定，加速腫瘤細胞侵襲轉移，同時誘導化療靶向藥物耐藥產生，是腫瘤不良預后重要標志物。CDK12 選擇性小分子抑制劑是全球腫瘤靶向研發熱門方向，多款候選藥物處于臨床前及早期臨床試驗階段，有望為晚期難治耐藥實體腫瘤提供精準全新治療選擇。
熱銷產品
Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial (CSB-EP882147HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數據
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA998940(CDK12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA998940(CDK12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
CDK12 Antibodies
CDK12 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA998940 | CDK12 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA882147LA01HU | CDK12 Antibody | Human | ELISA, WB |
CDK12 Proteins
CDK12 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005981XBF CSB-EP005981XBF CSB-BP005981XBF CSB-MP005981XBF CSB-EP005981XBF-B |
Recombinant Xenopus tropicalis Cyclin-dependent kinase 12 (cdk12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Ailuropoda melanoleuca (Giant panda)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005981AYX CSB-EP005981AYX CSB-BP005981AYX CSB-MP005981AYX CSB-EP005981AYX-B |
Recombinant Ailuropoda melanoleuca Cyclin-dependent kinase 12 (CDK12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005981BO CSB-EP005981BO CSB-BP005981BO CSB-MP005981BO CSB-EP005981BO-B |
Recombinant Bovine Cyclin-dependent kinase 12 (CDK12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP622934MO CSB-EP622934MO CSB-BP622934MO CSB-MP622934MO CSB-EP622934MO-B |
Recombinant Mouse Cyclin-dependent kinase 12 (Cdk12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP659533RA CSB-EP659533RA CSB-BP659533RA CSB-MP659533RA CSB-EP659533RA-B |
Recombinant Rat Cyclin-dependent kinase 12 (Cdk12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP882147HU CSB-MP882147HU CSB-EP882147HU-B |
Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP882147HU | Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial | E.coli |
| CSB-EP882147HUc7 | Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial | E.coli |
| CSB-EP882147HUb0 | Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial | E.coli |
| CSB-BP882147HU | Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial | Homo sapiens (Human) |
| CSB-BP882147HUa0 | Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial | Homo sapiens (Human) |
CDK12 Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP894718DLU CSB-BP894718DLU CSB-MP894718DLU CSB-EP894718DLU-B |
Recombinant Drosophila melanogaster Cyclin-dependent kinase 12 (Cdk12), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
