CDR2
CDR2,全稱為小腦變性相關蛋白2,常用別名有Yo抗原、CDR62、副腫瘤性小腦變性相關抗原。它主要在小腦浦肯野細胞中表達,參與維持小腦神經元存活與內質網結構穩定,對調控神經細胞正常生理狀態具有重要作用。
CDR2異常常引發自身免疫性神經損傷,是副腫瘤性小腦變性的核心靶抗原,多見于卵巢癌、乳腺癌等腫瘤患者伴隨的小腦共濟失調、運動協調障礙。臨床以免疫調節與腫瘤對癥治療為主,靶向CDR2的特異性抗體檢測已用于疾病診斷,針對該抗原的免疫干預藥物仍處于臨床前研發階段,有望為這類副腫瘤神經綜合征提供新的治療思路。
熱銷產品
Recombinant Human Cerebellar degeneration-related protein 2 (CDR2) (CSB-EP005103HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP005103HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP005103HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.
CDR2 Antibody (CSB-PA005103LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA005103LA01HU at dilution of 1:100
Western blot
All lanes: CDR2 antibody at 4µg/ml
Lane 1: Mouse lung tissue
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa
CDR2 Antibodies
CDR2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005103LA01HU | CDR2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA005103GA01HU | CDR2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA073505 | CDR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA283856 | CDR2 Antibody | Human,Mouse | ELISA,IHC |
CDR2 Proteins
CDR2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005103HU CSB-MP005103HU CSB-EP005103HU-B |
Recombinant Human Cerebellar degeneration-related protein 2 (CDR2) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP005103HU | Recombinant Human Cerebellar degeneration-related protein 2 (CDR2) | E.coli |
| CSB-BP005103HU | Recombinant Human Cerebellar degeneration-related protein 2(CDR2) | Baculovirus |




