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CDR2

CDR2,全稱為小腦變性相關蛋白2,常用別名有Yo抗原、CDR62、副腫瘤性小腦變性相關抗原。它主要在小腦浦肯野細胞中表達,參與維持小腦神經元存活與內質網結構穩定,對調控神經細胞正常生理狀態具有重要作用。
CDR2異常常引發自身免疫性神經損傷,是副腫瘤性小腦變性的核心靶抗原,多見于卵巢癌、乳腺癌等腫瘤患者伴隨的小腦共濟失調、運動協調障礙。臨床以免疫調節與腫瘤對癥治療為主,靶向CDR2的特異性抗體檢測已用于疾病診斷,針對該抗原的免疫干預藥物仍處于臨床前研發階段,有望為這類副腫瘤神經綜合征提供新的治療思路。

熱銷產品

Recombinant Human Cerebellar degeneration-related protein 2 (CDR2) (CSB-EP005103HU)

驗證數據

CSB-EP005103HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP005103HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP005103HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.

CSB-EP005103HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP005103HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.

CDR2 Antibody (CSB-PA005103LA01HU)

驗證數據

CSB-PA005103LA01HU

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA005103LA01HU at dilution of 1:100

CSB-PA005103LA01HU

Western blot
All lanes: CDR2 antibody at 4µg/ml
Lane 1: Mouse lung tissue
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa

CDR2 Antibodies

CDR2 for Homo sapiens (Human)

CDR2 Proteins

CDR2 Proteins for Homo sapiens (Human)



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