CDR2L
CDR2L，全稱(chēng)為小腦變性相關(guān)蛋白2樣蛋白，在神經(jīng)系統(tǒng)尤其是小腦區(qū)域的神經(jīng)元功能維持中扮演角色。它與同家族的CDR2蛋白存在結(jié)構(gòu)和功能關(guān)聯(lián)，常共同參與神經(jīng)元的正常生理活動(dòng)。
最值得關(guān)注的是CDR2L與副腫瘤性小腦變性的聯(lián)系：當(dāng)體內(nèi)出現(xiàn)小細(xì)胞肺癌、卵巢癌等腫瘤時(shí)，免疫系統(tǒng)可能產(chǎn)生針對(duì)CDR2L的自身抗體，這些抗體錯(cuò)誤攻擊小腦內(nèi)表達(dá)該蛋白的神經(jīng)元，引發(fā)步態(tài)不穩(wěn)、肢體協(xié)調(diào)障礙等癥狀。目前針對(duì)這類(lèi)疾病的治療多以免疫調(diào)節(jié)為主，比如使用免疫抑制劑減輕異常免疫反應(yīng)，或通過(guò)血漿置換清除致病抗體；部分研究正探索靶向這些自身抗體的特異性療法，但專(zhuān)門(mén)針對(duì)CDR2L的藥物仍處于早期研發(fā)階段，尚未進(jìn)入臨床應(yīng)用。
熱銷(xiāo)產(chǎn)品
Recombinant Human Cerebellar degeneration-related protein 2-like (CDR2L) (CSB-EP005104HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CDR2L Antibody (CSB-PA005104LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate
All lanes: CDR2L antibody at 7.1μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
IHC image of CSB-PA005104LA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
CDR2L Antibodies
CDR2L for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA005104GA01HU | CDR2L Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA005104LA01HU | CDR2L Antibody | Human | ELISA, WB, IHC |
| CSB-PA005104LC01HU | CDR2L Antibody, FITC conjugated | Human | |
| CSB-PA005104LD01HU | CDR2L Antibody, Biotin conjugated | Human | ELISA |
CDR2L Proteins
CDR2L Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP005104HU CSB-MP005104HU CSB-EP005104HU-B |
Recombinant Human Cerebellar degeneration-related protein 2-like (CDR2L) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP005104HU | Recombinant Human Cerebellar degeneration-related protein 2-like (CDR2L) | E.coli |
| CSB-BP005104HU | Recombinant Human Cerebellar degeneration-related protein 2-like (CDR2L) | Homo sapiens (Human) |
