CHEK1
CHEK1，別名CHK1、OZEMA21，是一種由人類基因編碼的Ser/Thr蛋白激酶家族成員，對響應(yīng)DNA損傷或未復(fù)制DNA存在的檢查點調(diào)節(jié)細(xì)胞周期停滯至關(guān)重要。CHEK1可整合來自ATM和ATR兩種參與DNA損傷應(yīng)答的細(xì)胞周期蛋白的信號，這些蛋白在減數(shù)分裂前期I中也與染色質(zhì)相關(guān)。CHEK1對CDC25A蛋白磷酸酶的磷酸化是必需的，以使細(xì)胞響應(yīng)雙鏈DNA斷裂而延遲細(xì)胞周期進(jìn)程。CHEK1參與DNA損傷檢查點信號傳導(dǎo)、G2/M轉(zhuǎn)換的有絲分裂細(xì)胞周期以及內(nèi)細(xì)胞團(tuán)細(xì)胞增殖等過程。它在染色質(zhì)、核和復(fù)制叉中發(fā)揮作用，并在多種組織中表達(dá)，包括腎上腺髓質(zhì)、早孕、性腺、直覺和來自神經(jīng)嵴的軀干間充質(zhì)。CHEK1的異常表達(dá)與多種癌癥相關(guān)，包括胰腺癌。
熱銷產(chǎn)品
CHEK1 Recombinant Monoclonal Antibody (CSB-RA176809A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: K562 whole cell lysate(30μg), 293T whole cell lysate(30μg), MCF7 whole cell lysate(30μg), HepG2 whole cell lysate(30μg), JK whole cell lysate(30μg), HL60 whole cell lysate(30μg),Raji whole cell lysate(30μg),Hela whole cell lysate(30μg)
All lanes: CHEK1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 55,44,51 kDa
Observed band size: 55 kDa
Exposure time: 10s
CHEK1 Antibodies
CHEK1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005338GA01HU | CHEK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA114140 | Phospho-CHEK1 (Ser280) Antibody | Human | ELISA,WB |
| CSB-PA245196 | CHEK1 (Ab-317) Antibody | Human,Rat | ELISA,WB,IHC |
| CSB-PA064953 | Phospho-CHEK1 (Ser286) Antibody | Human | ELISA,WB |
| CSB-PA779402 | Phospho-CHEK1 (Ser301) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA980870 | Phospho-CHEK1 (Ser296) Antibody | Human | ELISA,WB,IHC |
| CSB-PA584688 | CHEK1 (Ab-280) Antibody | Human | ELISA,WB |
| CSB-PA001623 | CHEK1 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA001626 | CHEK1 Antibody | Human | WB, IHC, ELISA |
| CSB-PA001629 | CHEK1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006767 | Phospho-CHEK1 (S280) Antibody | Human | WB, ELISA |
| CSB-PA006768 | Phospho-CHEK1 (S317) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006769 | Phospho-CHEK1 (S345) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA006770 | Phospho-CHEK1 (S286) Antibody | Human | WB, IF, ELISA |
| CSB-PA006771 | Phospho-CHEK1 (S301) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA006772 | Phospho-CHEK1 (S296) Antibody | Human | WB, IHC, ELISA |
| CSB-PA006773 | CHEK1 Antibody | Human | WB, ELISA |
| CSB-PA006774 | CHEK1 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA006775 | CHEK1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA927149 | CHEK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA005338LA01HU | CHEK1 Antibody | Human | ELISA |
| CSB-PA005338LB01HU | CHEK1 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA176809A0HU | CHEK1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
CHEK1 Proteins
CHEK1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005338HU CSB-EP005338HU CSB-BP005338HU CSB-MP005338HU CSB-EP005338HU-B |
Recombinant Human Serine/threonine-protein kinase Chk1 (CHEK1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CHEK1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005338MO CSB-EP005338MO CSB-BP005338MO CSB-MP005338MO CSB-EP005338MO-B |
Recombinant Mouse Serine/threonine-protein kinase Chk1 (Chek1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CHEK1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP738530XBE CSB-EP738530XBE CSB-BP738530XBE CSB-MP738530XBE CSB-EP738530XBE-B |
Recombinant Xenopus laevis Serine/threonine-protein kinase Chk1 (chek1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CHEK1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP806796CH CSB-EP806796CH CSB-BP806796CH CSB-MP806796CH CSB-EP806796CH-B |
Recombinant Chicken Serine/threonine-protein kinase Chk1 (CHEK1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CHEK1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP846015RA CSB-MP846015RA CSB-EP846015RA-B |
Recombinant Rat Serine/threonine-protein kinase Chk1 (Chek1) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
