CHRM5
CHRM5，即毒蕈堿型乙酰膽堿受體M5亞型，常被簡稱為M5受體。它是乙酰膽堿信號網絡中的關鍵成員，主要分布在大腦的多巴胺能神經元區域（如中腦腹側被蓋區、黑質），能參與調控多巴胺的釋放過程。CHRM5功能異?？赡芘c多種神經系統疾病相關：比如精神分裂癥患者的大腦中M5受體表達水平常出現改變，它也被認為和帕金森病的運動障礙、認知缺陷存在關聯。在藥物開發領域，目前有一些針對M5受體的選擇性化合物處于臨床前研究階段，這些候選藥物試圖通過調節M5受體的活性，來緩解精神分裂癥的陽性癥狀（如幻覺、妄想）或改善帕金森病的認知問題，但尚未有相關藥物正式獲批上市。
熱銷產品
Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5) (CSB-CF005385HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CHRM5 Antibody (CSB-PA005385LA01HU)
驗證數據
Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
All lanes: CHRM5 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61 kDa
Observed band size: 61 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005385LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA005385LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CHRM5 Antibodies
CHRM5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006813 | CHRM5 Antibody | Human | WB, IF, ELISA |
| CSB-PA985994 | CHRM5 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA598098 | CHRM5 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA005385LA01HU | CHRM5 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CHRM5 Proteins
CHRM5 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005385MOW1 CSB-EP005385MOW1 CSB-BP005385MOW1 CSB-MP005385MOW1 CSB-EP005385MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) Muscarinic acetylcholine receptor M5 (CHRM5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005385MOW | Recombinant Macaca mulatta (Rhesus macaque) Muscarinic acetylcholine receptor M5 (CHRM5) | in vitro E.coli expression system |
CHRM5 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005385RA1 CSB-EP005385RA1 CSB-BP005385RA1 CSB-MP005385RA1 CSB-EP005385RA1-B |
Recombinant Rat Muscarinic acetylcholine receptor M5 (Chrm5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005385RA | Recombinant Rat Muscarinic acetylcholine receptor M5 (Chrm5) | in vitro E.coli expression system |
CHRM5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005385HU1 CSB-BP005385HU1 CSB-MP005385HU1 CSB-EP005385HU1-B |
Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005385HU | Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5) | in vitro E.coli expression system |
| CSB-EP005385HU1 | Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5), partial | E.coli |
| CSB-MP005385HU | Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5)-VLPs | Mammalian cell |
CHRM5 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP683299EQV1 CSB-EP683299EQV1 CSB-BP683299EQV1 CSB-MP683299EQV1 CSB-EP683299EQV1-B |
Recombinant Pan troglodytes Muscarinic acetylcholine receptor M5 (CHRM5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF683299EQV | Recombinant Pan troglodytes Muscarinic acetylcholine receptor M5 (CHRM5) | in vitro E.coli expression system |
CHRM5 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP702443SWC1 CSB-EP702443SWC1 CSB-BP702443SWC1 CSB-MP702443SWC1 CSB-EP702443SWC1-B |
Recombinant Saimiri boliviensis boliviensis Muscarinic acetylcholine receptor M5 (CHRM5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF702443SWC | Recombinant Saimiri boliviensis boliviensis Muscarinic acetylcholine receptor M5 (CHRM5) | in vitro E.coli expression system |
CHRM5 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP856351MO1 CSB-EP856351MO1 CSB-BP856351MO1 CSB-MP856351MO1 CSB-EP856351MO1-B |
Recombinant Mouse Muscarinic acetylcholine receptor M5 (Chrm5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF856351MO | Recombinant Mouse Muscarinic acetylcholine receptor M5 (Chrm5) | in vitro E.coli expression system |
