CHRNB1
CHRNB1，全稱為煙堿型乙酰膽堿受體β1亞基，常被簡稱為nAChRβ1，是神經(jīng)肌肉接頭處乙酰膽堿受體的核心組成部分。它與其他亞基共同搭建起離子通道，當(dāng)神經(jīng)遞質(zhì)乙酰膽堿與之結(jié)合時，通道會打開，允許離子跨膜流動，從而完成神經(jīng)信號到肌肉的傳遞，保障肌肉正常收縮。
若CHRNB1出現(xiàn)異常，可能干擾神經(jīng)與肌肉間的信號溝通，比如重癥肌無力患者體內(nèi)會產(chǎn)生針對它的自身抗體，導(dǎo)致肌肉無力、活動后易疲勞等癥狀。目前臨床常用膽堿酯酶抑制劑緩解癥狀，這類藥物能減少乙酰膽堿的分解，增強(qiáng)信號傳遞效果；同時也有研究在開發(fā)靶向異常抗體的生物制劑，以期更精準(zhǔn)地改善患者病情。
熱銷產(chǎn)品
Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial (CSB-EP005395HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CHRNB1 Antibody (CSB-PA15049A0Rb)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: CHRNB1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 50 kDa
Observed band size: 57 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA15049A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA15049A0Rb at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA15049A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CHRNB1 Antibodies
CHRNB1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005395GA01HU | CHRNB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA437943 | CHRNB1 Antibody | Human | ELISA,WB |
| CSB-PA006822 | CHRNB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA15049A0Rb | CHRNB1 Antibody | Human | ELISA, WB, IHC, IF |
CHRNB1 Proteins
CHRNB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP005395HU CSB-MP005395HU CSB-EP005395HU-B |
Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP005395HU | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | E.coli |
| CSB-EP005395HUb1 | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | E.coli |
| CSB-YP005395HU | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | Yeast |
