CLDN3

CLDN3，全稱為Claudin-3，常見(jiàn)別名CLDN-3，是緊密連接蛋白家族中的關(guān)鍵成員。它廣泛分布于胃腸道、乳腺等上皮組織，作為細(xì)胞間緊密連接的核心組件，能讓相鄰上皮細(xì)胞緊密貼合，維持組織屏障的完整性，調(diào)控營(yíng)養(yǎng)物質(zhì)與有害物質(zhì)的跨膜轉(zhuǎn)運(yùn)，保障機(jī)體正常生理功能。
當(dāng)Claudin-3表達(dá)異常時(shí)，易引發(fā)多種疾病：在胃癌、乳腺癌等惡性腫瘤中，其表達(dá)水平改變常與腫瘤細(xì)胞侵襲、轉(zhuǎn)移能力增強(qiáng)相關(guān)；炎癥性腸病患者中，Claudin-3功能失調(diào)會(huì)導(dǎo)致腸道屏障受損，加重炎癥反應(yīng)。目前針對(duì)Claudin-3的藥物研發(fā)逐步推進(jìn)，部分靶向該蛋白的單克隆抗體已進(jìn)入臨床前或早期臨床試驗(yàn)階段，有望為相關(guān)疾病治療提供新方向。

熱銷產(chǎn)品

Recombinant Human Claudin-3 (CLDN3)-VLPs (Active) (CSB-MP005505HU)

驗(yàn)證數(shù)據(jù)

CSB-MP005505HU is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN3 at 10μg/mL can bind Anti-CLDN3 recombinant antibody (CSB-RA005505MA1HU)， the EC₅₀ is 23.62-34.37 ng/mL.VLPs (CSB-MP3838) is negative control.

Recombinant Human Claudin-3 (CLDN3) (CSB-CF005505HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CLDN3 Recombinant Monoclonal Antibody (CSB-RA005505MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of CLDN3 with Anti-CLDN3 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN3 (CSB-MP005505HU) at 10 μg/mL can bind Anti-CLDN3 recombinant antibody, the EC₅₀ is 23.62-34.37 ng/mL.VLPs (CSB-MP3838) is negative control.

CLDN3 Antibody

CLDN3 Protein

CLDN3 ELISA Kit

CLDN3 Antibodies

CLDN3 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA005505GA01HU	CLDN3 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA193301	CLDN3 Antibody	Human	ELISA,WB,IHC,IF
CSB-PA001661	CLDN3 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA007223	Phospho-CLDN3 (Y219) Antibody	Human	WB, IHC, ELISA
CSB-PA007225	CLDN3 Antibody	Human	WB, IHC, ELISA
CSB-PA561954	CLDN3 Antibody	Human	ELISA,WB,IHC
CSB-PA068230	CLDN3 Antibody	Human	ELISA,IHC
CSB-PA13119A0Rb	CLDN3 Antibody	Human	ELISA, WB, IHC
CSB-PA13119B0Rb	CLDN3 Antibody, HRP conjugated	Human	ELISA
CSB-PA13119D0Rb	CLDN3 Antibody, Biotin conjugated	Human	ELISA
CSB-RA005505MA1HU	CLDN3 Recombinant Monoclonal Antibody	Human	ELISA

CLDN3 Proteins

CLDN3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005505HU1 CSB-EP005505HU1 CSB-BP005505HU1 CSB-MP005505HU1 CSB-EP005505HU1-B	Recombinant Human Claudin-3 (CLDN3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF005505HU	Recombinant Human Claudin-3 (CLDN3)	in vitro E.coli expression system
CSB-EP005505HU1a6	Recombinant Human Claudin-3 (CLDN3), partial	E.coli
CSB-MP005505HU	Recombinant Human Claudin-3 (CLDN3)-VLPs (Active)	Mammalian cell

CLDN3 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP723578RA1 CSB-EP723578RA1 CSB-BP723578RA1 CSB-MP723578RA1 CSB-EP723578RA1-B	Recombinant Rat Claudin-3 (Cldn3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF723578RA	Recombinant Rat Claudin-3 (Cldn3)	in vitro E.coli expression system

CLDN3 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP748461BO1 CSB-EP748461BO1 CSB-BP748461BO1 CSB-MP748461BO1 CSB-EP748461BO1-B	Recombinant Bovine Claudin-3 (CLDN3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF748461BO	Recombinant Bovine Claudin-3 (CLDN3)	in vitro E.coli expression system

CLDN3 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP842554DO1 CSB-EP842554DO1 CSB-BP842554DO1 CSB-MP842554DO1 CSB-EP842554DO1-B	Recombinant Dog Claudin-3 (CLDN3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CLDN3 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP897449MO1 CSB-EP897449MO1 CSB-BP897449MO1 CSB-MP897449MO1 CSB-EP897449MO1-B	Recombinant Mouse Claudin-3 (Cldn3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF897449MO	Recombinant Mouse Claudin-3 (Cldn3)	in vitro E.coli expression system