CLDN4

CLDN4，全稱為Claudin-4，也常被簡稱為CLD4，是緊密連接蛋白家族的重要成員。它主要分布在上皮與內皮細胞之間，像細胞間的“分子黏合劑”，幫助維持細胞連接的緊密性，調控物質在細胞間隙的正常轉運，保障組織屏障的穩定。
在疾病領域，Claudin-4的異常表達與多種癌癥密切相關，比如胰腺癌、胃癌等。腫瘤中它的水平往往明顯升高，這會破壞細胞間的緊密連接，讓腫瘤細胞更容易侵襲周圍組織或發生轉移，同時它也可能作為腫瘤診斷的潛在指標。目前針對Claudin-4的靶向治療研究正在開展，一些特異性抗體藥物已進入早期臨床試驗，試圖通過干預它的功能來抑制腫瘤進展，為相關癌癥治療帶來新希望。

熱銷產品

Recombinant Human Claudin-4 (CLDN4)-VLPs (Active) (CSB-MP005506HU)

驗證數據

CSB-MP005506HU is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN4 at 5 μg/ml can bind Anti-CLDN4 recombinant antibody (CSB-RA005506MA1HU), the EC₅₀ is 29.56-50.75 ng/mL.

Recombinant Human Claudin-4 (CLDN4)-Detergent (CSB-MP005506HU-D)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CLDN4 Recombinant Monoclonal Antibody (CSB-RA005506MA1HU)

驗證數據

The Binding Activity of Human CLDN4 with Anti-CLDN4 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN4(CSB-MP005506HU) at 5 μg/mL can bind Anti-CLDN4 recombinant antibody, the EC₅₀ is 29.56-50.75 ng/mL.

Human Claudin 4 (CLDN4)ELISA Kit (CSB-E17961h)

驗證數據

貨號：CSB-E17961h

規格：96T/48T

靈敏度：1.56 pg/mL

檢測范圍：6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CLDN4 Antibody

CLDN4 Protein

CLDN4 ELISA Kit

CLDN4 Antibodies

CLDN4 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA005506GA01HU	CLDN4 Antibody	Human, Mouse, Rat	ELISA, WB
CSB-PA001662	CLDN4 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA007220	Phospho-CLDN4 (Y208) Antibody	Human	IHC, ELISA
CSB-PA007221	CLDN4 Antibody	Human	WB, IHC, ELISA
CSB-PA086155	CLDN4 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA275606	CLDN4 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-RA005506A0HU	CLDN4 Recombinant Monoclonal Antibody	Human	ELISA
CSB-RA005506MA1HU	CLDN4 Recombinant Monoclonal Antibody	Human	ELISA
CSB-RA005506MA2HU	CLDN4 Recombinant Monoclonal Antibody	Human	ELISA, FC

CLDN4 Proteins

CLDN4 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP005506HU1 CSB-EP005506HU1 CSB-BP005506HU1 CSB-MP005506HU1 CSB-EP005506HU1-B	Recombinant Human Claudin-4 (CLDN4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF005506HU	Recombinant Human Claudin-4 (CLDN4)	in vitro E.coli expression system
CSB-MP005506HU	Recombinant Human Claudin-4 (CLDN4)-VLPs (Active)	Mammalian cell
CSB-MP005506HU-D	Recombinant Human Claudin-4 (CLDN4)-Detergent	Mammalian cell

CLDN4 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP005506MO1 CSB-EP005506MO1 CSB-BP005506MO1 CSB-MP005506MO1 CSB-EP005506MO1-B	Recombinant Mouse Claudin-4 (Cldn4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF005506MO	Recombinant Mouse Claudin-4 (Cldn4)	in vitro E.coli expression system

CLDN4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

產品貨號	產品名稱	來源
CSB-YP005506DSU1 CSB-EP005506DSU1 CSB-BP005506DSU1 CSB-MP005506DSU1 CSB-EP005506DSU1-B	Recombinant Chlorocebus aethiops Claudin-4 (CLDN4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF005506DSU	Recombinant Chlorocebus aethiops Claudin-4 (CLDN4)	in vitro E.coli expression system

CLDN4 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP718376BO1 CSB-EP718376BO1 CSB-BP718376BO1 CSB-MP718376BO1 CSB-EP718376BO1-B	Recombinant Bovine Claudin-4 (CLDN4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF718376BO	Recombinant Bovine Claudin-4 (CLDN4)	in vitro E.coli expression system