CLDN5
CLDN5，即Claudin-5，也常被稱為CLD5，是緊密連接蛋白家族里的關鍵成員。它主要分布在血管內(nèi)皮細胞，尤其是腦微血管的內(nèi)皮細胞上，能讓相鄰細胞緊密貼合，形成一道堅固的屏障——比如血腦屏障，既能阻止血液里的有害物質(zhì)隨意進入腦組織，又能保證營養(yǎng)和氧氣順利通過，維持大腦環(huán)境穩(wěn)定。
當Claudin-5的功能出問題時，屏障的完整性會被破壞。比如多發(fā)性硬化患者中，炎癥反應會降低它的表達，讓血腦屏障通透性增加，免疫細胞和炎癥因子侵入腦組織，加重神經(jīng)損傷；腦膠質(zhì)瘤也會影響它的正常功能，使腫瘤區(qū)域的屏障出現(xiàn)漏洞，既讓腫瘤細胞更容易擴散，也給藥物進入腦內(nèi)治療帶來阻礙。目前，一些研究正探索調(diào)節(jié)Claudin-5的方法：有的想增強它的表達來修復受損屏障，幫助治療神經(jīng)系統(tǒng)疾病；有的嘗試暫時調(diào)控它打開血腦屏障，讓抗癌藥物更有效地到達腦腫瘤部位。
熱銷產(chǎn)品
CLDN5 Recombinant Monoclonal Antibody (CSB-RA037143A0HU)
驗證數(shù)據(jù)
IHC image of CSB-RA037143A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.77% DAB.
CLDN5 Antibody (CSB-PA005507LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA005507LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA005507LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Claudin-5(CLDN5) ELISA kit (CSB-EL005507HU)
驗證數(shù)據(jù)
貨號：CSB-EL005507HU
規(guī)格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CLDN5 Antibodies
CLDN5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA275485 | CLDN5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA554477 | Phospho-CLDN5 (Tyr217) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA166761 | CLDN5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001672 | CLDN5 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA050270 | Phospho-CLDN5 (Y217) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA050271 | CLDN5 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA285560 | CLDN5 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA578073 | CLDN5 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA005507LA01HU | CLDN5 Antibody | Human | ELISA, IHC, IF |
| CSB-PA005507LC01HU | CLDN5 Antibody, FITC conjugated | Human | |
| CSB-RA037143A0HU | CLDN5 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CLDN5 Proteins
CLDN5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005507HU1 CSB-EP005507HU1 CSB-BP005507HU1 CSB-MP005507HU1 CSB-EP005507HU1-B |
Recombinant Human Claudin-5 (CLDN5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005507HU | Recombinant Human Claudin-5 (CLDN5) | in vitro E.coli expression system |
CLDN5 ELISA Kit
CLDN5 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL005507HU | Human Claudin-5(CLDN5) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
