COL11A1

COL11A1，全稱為 XI 型膠原蛋白 α1 鏈，常用別名膠原 11A1。它是細(xì)胞外基質(zhì)重要結(jié)構(gòu)蛋白，主要參與軟骨形成、骨骼發(fā)育、組織間質(zhì)結(jié)構(gòu)維持以及細(xì)胞黏附支撐，對(duì)關(guān)節(jié)軟骨穩(wěn)定、骨骼發(fā)育成熟和機(jī)體結(jié)締組織完整結(jié)構(gòu)至關(guān)重要。
COL11A1 異常表達(dá)與骨關(guān)節(jié)炎、軟骨退變疾病相關(guān)，同時(shí)在肺癌、胰腺癌、卵巢癌等腫瘤中顯著升高，會(huì)重塑腫瘤間質(zhì)微環(huán)境，增強(qiáng)腫瘤細(xì)胞侵襲遷移能力，加速腫瘤惡性進(jìn)展并提示不良預(yù)后。目前 COL11A1 靶向干預(yù)分子處于臨床前探索階段，通過改善間質(zhì)異常重塑，有望用于骨關(guān)節(jié)疾病及惡性腫瘤的治療開發(fā)。

熱銷產(chǎn)品

Recombinant Human Collagen alpha-1(XI) chain (COL11A1), partial (CSB-EP005716HUc7)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

COL11A1 Antibody (CSB-PA005716LA01HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA005716LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Collagen alpha-1(XI) chain (COL11A1) ELISA kit (CSB-EL005716HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL005716HU

規(guī)格：96T/48T

靈敏度：15.6 pg/mL

檢測范圍：62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

COL11A1 Antibody

COL11A1 Protein

COL11A1 ELISA Kit

COL11A1 Antibodies

COL11A1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA005716LB01HU	COL11A1 Antibody, HRP conjugated	Human	ELISA
CSB-PA005716LA01HU	COL11A1 Antibody	Human	ELISA, IHC
CSB-PA005716LD01HU	COL11A1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA007113	COL11A1 Antibody	Human,Mouse	WB, IHC, IF, ELISA

COL11A1 Proteins

COL11A1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP005716HU	Recombinant Human Collagen alpha-1 (XI) chain (COL11A1), partial	Yeast
CSB-EP005716HU CSB-BP005716HU CSB-MP005716HU CSB-EP005716HU-B	Recombinant Human Collagen alpha-1 (XI) chain (COL11A1), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP005716HUc0	Recombinant Human Collagen alpha-1 (XI) chain (COL11A1), partial	E.coli
CSB-EP005716HUc7	Recombinant Human Collagen alpha-1(XI) chain (COL11A1), partial	E.coli

COL11A1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP005716RA CSB-EP005716RA CSB-BP005716RA CSB-MP005716RA CSB-EP005716RA-B	Recombinant Rat Collagen alpha-1 (XI) chain (Col11a1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL11A1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP632955BO CSB-EP632955BO CSB-BP632955BO CSB-MP632955BO CSB-EP632955BO-B	Recombinant Bovine Collagen alpha-1 (XI) chain (COL11A1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

COL11A1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP736811MO CSB-BP736811MO CSB-MP736811MO CSB-EP736811MO-B	Recombinant Mouse Collagen alpha-1 (XI) chain (Col11a1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli