CSNK1A1
CSNK1A1，全稱為酪蛋白激酶1α1，常用別名CK1α。它是細胞內一種重要的酶，能通過修飾其他蛋白質參與多種生理活動——比如維持人體正常的生物鐘節律，調控細胞生長分裂的節奏，還會影響細胞對外界信號的反應方式。當CSNK1A1功能異常時，可能引發多種疾病：在急性髓系白血病中，它的活性變化會助推癌細胞增殖；部分神經退行性疾病（如阿爾茨海默病）里，它與Tau蛋白的異常修飾相關，可能加重病情；此外還和一些實體瘤的發展有關。目前針對CK1α的藥物研發多聚焦于癌癥治療，一些小分子抑制劑正處于臨床前或早期試驗階段，實驗室研究顯示它們能抑制腫瘤細胞生長，有望為相關疾病帶來新的治療方向。
熱銷產品
Recombinant Human Casein kinase I isoform alpha (CSNK1A1) (CSB-EP006065HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006065HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CSNK1A1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006065HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CSNK1A1.
CSNK1A1 Recombinant Monoclonal Antibody (CSB-RA973184A0HU)
驗證數據
Western blotting analysis using CSNK1A1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CSNK1A1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
CSNK1A1 Antibody (CSB-PA006065LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA006065LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006065LA01HU at dilution of 1:100
CSNK1A1 Antibodies
CSNK1A1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006065LA01HU | CSNK1A1 Antibody | Human | ELISA, IHC |
| CSB-PA833830 | CSNK1A1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA001224 | CSNK1A1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA001225 | CSNK1A1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007354 | Phospho-CSNK1A1 (Y321) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA276669 | CSNK1A1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA973184A0HU | CSNK1A1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
CSNK1A1 Proteins
CSNK1A1 Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065SH CSB-EP006065SH CSB-BP006065SH CSB-MP006065SH CSB-EP006065SH-B |
Recombinant Sheep Casein kinase I isoform alpha (CSNK1A1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSNK1A1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065CH CSB-EP006065CH CSB-BP006065CH CSB-MP006065CH CSB-EP006065CH-B |
Recombinant Chicken Casein kinase I isoform alpha (CSNK1A1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSNK1A1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065RB CSB-EP006065RB CSB-BP006065RB CSB-MP006065RB CSB-EP006065RB-B |
Recombinant Rabbit Casein kinase I isoform alpha (CSNK1A1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSNK1A1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065BO CSB-EP006065BO CSB-BP006065BO CSB-MP006065BO CSB-EP006065BO-B |
Recombinant Bovine Casein kinase I isoform alpha (CSNK1A1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSNK1A1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065HU CSB-BP006065HU CSB-MP006065HU CSB-EP006065HU-B |
Recombinant Human Casein kinase I isoform alpha (CSNK1A1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006065HU | Recombinant Human Casein kinase I isoform alpha (CSNK1A1) | E.coli |
CSNK1A1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065PI CSB-EP006065PI CSB-BP006065PI CSB-MP006065PI CSB-EP006065PI-B |
Recombinant Pig Casein kinase I isoform alpha (CSNK1A1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSNK1A1 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065XBE CSB-EP006065XBE CSB-BP006065XBE CSB-MP006065XBE CSB-EP006065XBE-B |
Recombinant Xenopus laevis Casein kinase I isoform alpha (csnk1a1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSNK1A1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006065RA CSB-EP006065RA CSB-BP006065RA CSB-MP006065RA CSB-EP006065RA-B |
Recombinant Rat Casein kinase I isoform alpha (Csnk1a1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSNK1A1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP805291MO CSB-EP805291MO CSB-BP805291MO CSB-MP805291MO CSB-EP805291MO-B |
Recombinant Mouse Casein kinase I isoform alpha (Csnk1a1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
