CXCL1
CXCL1，全稱為Chemokine (C-X-C motif) ligand 1，是一種小分子的細胞因子，屬于CXC趨化因子家族。它也被稱為生長調節致癌基因α (GROα)、melanoma growth stimulating activity、alpha (MGSA-a)、NAP-3 或 SCYB1。CXCL1主要由巨噬細胞、中性粒細胞和上皮細胞表達，對中性粒細胞具有趨化作用，能夠吸引中性粒細胞遷移到感染或損傷部位。CXCL1通過與趨化因子受體CXCR2結合，參與炎癥反應、傷口愈合和腫瘤形成等多種生理過程。在炎癥反應中，CXCL1能夠促進白細胞遷移到受損部位，增強單核細胞與內皮細胞之間的粘附，刺激單核細胞的聚集和活化，并促進單核細胞穿過內皮細胞屏障，最終形成泡沫細胞，從而參與動脈粥樣硬化的形成。此外，CXCL1還與多種疾病的發生發展密切相關，如腫瘤、動脈粥樣硬化、風濕性關節炎等。目前，針對CXCL1的藥物研發主要集中在抑制其活性或阻斷其與受體的結合，以期達到抗炎、抗腫瘤等治療目的。
熱銷產品
Recombinant Human Growth-regulated alpha protein (CXCL1) (Active) (CSB-MP006239HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human CXCL1 at 2 μg/ml can bind anti-CXCL3 recombinant antibody(CSB-RA006249MA1HU).The EC50 is 4.181-4.921 ng/mL.
Activity
CXCL3 Recombinant Monoclonal Antibody(CSB-RA006249MA1HU) captured on Protein A Chip can bind Human CXCL1 with an affinity constant of 0.143 nM as detected by MetaSPR Assay (WeSPRTM 200).
Recombinant Human Growth-regulated alpha protein (CXCL1) (CSB-EP006239HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CXCL1 Antibodies
CXCL1 for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA09217A0Rb | Cxcl1 Antibody | Mouse | ELISA |
| CSB-PA09217C0Rb | Cxcl1 Antibody, FITC conjugated | Mouse |
CXCL1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA06097A0Rb | CXCL1 Antibody | Human | ELISA |
| CSB-PA06097C0Rb | CXCL1 Antibody, FITC conjugated | Human | |
| CSB-PA06097D0Rb | CXCL1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA006239GA01HU | CXCL1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA009036 | CXCL1 Antibody | Human,Mouse,Rat | IHC, ELISA |
CXCL1 Proteins
CXCL1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006239MO CSB-EP006239MO CSB-BP006239MO CSB-MP006239MO CSB-EP006239MO-B |
Recombinant Mouse Growth-regulated alpha protein (Cxcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP092174m | Recombinant Mouse Growth-regulated alpha protein (Cxcl1), partial | E.coli |
| CSB-AP001061MO | Recombinant Mouse Growth-regulated alpha protein (Cxcl1) | E.Coli |
CXCL1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006239RA CSB-EP006239RA CSB-BP006239RA CSB-MP006239RA CSB-EP006239RA-B |
Recombinant Rat Growth-regulated alpha protein (Cxcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001391RA | Recombinant Rat Growth-regulated alpha protein (Cxcl1) | E.Coli |
CXCL1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006239HU CSB-BP006239HU CSB-EP006239HU-B |
Recombinant Human Growth-regulated alpha protein (CXCL1) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP006239HU | Recombinant Human Growth-regulated alpha protein (CXCL1) | E.coli |
| CSB-AP000631HU | Recombinant Human Growth-regulated alpha protein (CXCL1) | E.Coli |
| CSB-EP006239HUa2 | Recombinant Human Growth-regulated alpha protein (CXCL1) | E.coli |
CXCL1 Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006239SH CSB-EP006239SH CSB-BP006239SH CSB-MP006239SH CSB-EP006239SH-B |
Recombinant Sheep Growth-regulated alpha protein (CXCL1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCL1 Proteins for Cavia porcellus (Guinea pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006239GU CSB-EP006239GU CSB-BP006239GU CSB-MP006239GU CSB-EP006239GU-B |
Recombinant Guinea pig Growth-regulated alpha protein (CXCL1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCL1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006239DXU CSB-EP006239DXU CSB-BP006239DXU CSB-MP006239DXU CSB-EP006239DXU-B |
Recombinant Cricetulus griseus Growth-regulated alpha protein (CXCL1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCL1 ELISA Kit
CXCL1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09150h | Human growth-regulated oncogeneα/melanoma growth stimulating activity,GROα/MGSA ELISA Kit | serum, plasma, tissue homogenates | 19.5 pg/ml |
CXCL1 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17286m | Mouse chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
CXCL1 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12997r | Rat growth-regulated oncogene α/melanoma growth stimulating activity,GROα /MGSA Elisa Kit | serum, plasma, tissue homogenates | 31.25 pg/mL |
