DNER
DNER，全稱為Delta/Notch樣表皮生長因子相關受體，常用別名有BET、Bret。它是一種神經組織富集的跨膜蛋白，主要分布在小腦浦肯野細胞與內耳螺旋神經元，參與神經元與膠質細胞的交互調控，對小腦發育、突觸形成及運動協調維持起到關鍵作用。
DNER表達異常與自身免疫性腦炎、小腦共濟失調密切相關，也是抗TR/DNER抗體腦炎的核心靶抗原。同時其高表達會推動肝癌、胃癌、前列腺癌等腫瘤的增殖與侵襲，提示不良預后。目前以靶向DNER的抗體檢測用于神經系統自身免疫病診斷，針對該蛋白的小分子抑制劑與抗體藥物正處于臨床前研發，有望為神經免疫疾病與惡性腫瘤提供新的治療方案。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DNER Antibody (CSB-PA818784NA01HU)
驗證數據
Immunofluorescence staining of U87 cells with CSB-PA818784NA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
DNER Antibodies
DNER for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA818784NA01HU | DNER Antibody | Human | ELISA, IF |
| CSB-PA818784NB01HU | DNER Antibody, HRP conjugated | Human | ELISA |
| CSB-PA818784NC01HU | DNER Antibody, FITC conjugated | Human | |
| CSB-PA818784ND01HU | DNER Antibody, Biotin conjugated | Human | ELISA |
DNER Proteins
DNER Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP818784HU-B |
Recombinant Human Delta and Notch-like epidermal growth factor-related receptor (DNER), partial | In Vivo Biotinylation in E.coli |
| CSB-EP818784HU | Recombinant Human Delta and Notch-like epidermal growth factor-related receptor (DNER), partial | E.coli |
| CSB-YP818784HU | Recombinant Human Delta and Notch-like epidermal growth factor-related receptor (DNER), partial | Yeast |
| CSB-MP818784HU | Recombinant Human Delta and Notch-like epidermal growth factor-related receptor (DNER), partial | Mammalian cell |
| CSB-MP818784HUd7 | Recombinant Human Delta and Notch-like epidermal growth factor-related receptor (DNER), partial | Mammalian cell |
| CSB-BP818784HU | Recombinant Human Delta and Notch-like epidermal growth factor-related receptor (DNER), partial | Baculovirus |
