DNM1
DNM1，全稱(chēng)為動(dòng)力蛋白1，別名包括DNM1（動(dòng)力蛋白1）。該蛋白主要參與細(xì)胞內(nèi)的膜運(yùn)輸和突觸小泡的循環(huán)過(guò)程，在神經(jīng)系統(tǒng)中尤為重要。它通過(guò)其GTP酶活性介導(dǎo)突觸小泡的形成和分離，從而參與多種細(xì)胞過(guò)程。DNM1蛋白在多種疾病中發(fā)揮作用，包括一些遺傳性腦病，如發(fā)育和癲癇性腦病31A。這些疾病通常表現(xiàn)為嚴(yán)重的智力障礙、癲癇發(fā)作和運(yùn)動(dòng)障礙。目前，針對(duì)DNM1蛋白的藥物研發(fā)主要集中在開(kāi)發(fā)能夠恢復(fù)其正常功能的方法，以期治療相關(guān)疾病。例如，一些研究正在探索通過(guò)基因治療手段恢復(fù)DNM1蛋白功能，以治療DNM1腦病。此外，DNM1蛋白也被發(fā)現(xiàn)與卵巢癌的轉(zhuǎn)移密切相關(guān)，抑制其活性可以有效減少癌細(xì)胞的擴(kuò)散，為卵巢癌的治療提供了新的思路。
熱銷(xiāo)產(chǎn)品
Recombinant Human Dynamin-1-like protein (DNM1L) (CSB-EP007078HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007078HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DNM1L.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007078HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DNM1L.
DNM1L Antibody (CSB-PA007078EA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate, Mouse heart tissue
All lanes: DNM1L antibody at 0.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 82, 81, 80, 79, 84, 61, 83 kDa
Observed band size: 82 kDa
Immunohistochemistry analysis of human cervical cancer using CSB-PA007078EA01HU at dilution of 1:100
Immunohistochemistry analysis of human brain tissue using CSB-PA007078EA01HU at dilution of 1:100
DNM1 Antibodies
DNM1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA007062GA01HU | DNM1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007078GA01HU | DNM1L Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007062LA01HU | DNM1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA051297 | DNM1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA058486 | Phospho-DNM1 (Ser774) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA297783 | Phospho-DNM1L (Ser637) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA825071 | DNM1L (Ab-637) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA138782 | Phospho-DNM1 (Ser778) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002203 | DNM1L Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA002221 | DNM1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006377 | Phospho-DNM1L (S637) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007806 | Phospho-DNM1 (S778) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007807 | Phospho-DNM1 (S774) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007808 | DNM1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA617795 | DNM1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA448541 | DNM1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007078EA01HU | DNM1L Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA007078EB01HU | DNM1L Antibody, HRP conjugated | Human | ELISA |
DNM1 Proteins
DNM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007062HU | Recombinant Human Dynamin-1 (DNM1), partial | Yeast |
| CSB-YP007078HU CSB-BP007078HU CSB-MP007078HU CSB-EP007078HU-B |
Recombinant Human Dynamin-1-like protein (DNM1L) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007062HU | Recombinant Human Dynamin-1 (DNM1), partial | E.coli |
| CSB-BP007062HU CSB-MP007062HU CSB-EP007062HU-B |
Recombinant Human Dynamin-1 (DNM1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007078HU | Recombinant Human Dynamin-1-like protein (DNM1L) | E.coli |
| CSB-EP007062HUa0 | Recombinant Human Dynamin-1 (DNM1), partial | E.coli |
DNM1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007062RA CSB-EP007062RA CSB-BP007062RA CSB-MP007062RA CSB-EP007062RA-B |
Recombinant Rat Dynamin-1 (Dnm1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNM1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007062MO CSB-EP007062MO CSB-BP007062MO CSB-MP007062MO CSB-EP007062MO-B |
Recombinant Mouse Dynamin-1 (Dnm1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNM1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP345810SVG CSB-EP345810SVG CSB-BP345810SVG CSB-MP345810SVG CSB-EP345810SVG-B |
Recombinant Saccharomyces cerevisiae Dynamin-related protein DNM1 (DNM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNM1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP601029SXV CSB-EP601029SXV CSB-BP601029SXV CSB-MP601029SXV CSB-EP601029SXV-B |
Recombinant Schizosaccharomyces pombe Dynamin-like protein C12C2.08 (SPBC12C2.08), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
