DSG2
DSG2，全稱為橋粒芯糖蛋白2，是橋粒家族的重要成員，常見別名有DSG、CD134。它就像細(xì)胞間的“黏合劑”，能讓相鄰細(xì)胞緊密連接，維持心臟、皮膚等組織的結(jié)構(gòu)穩(wěn)定——比如在心肌細(xì)胞間，它幫助保持細(xì)胞排列整齊，確保心臟收縮時結(jié)構(gòu)不松散。
若DSG2功能異常，可能引發(fā)多種疾病：心臟方面易導(dǎo)致致心律失常性右室心肌病，患者心肌逐漸被脂肪或纖維組織取代，出現(xiàn)心跳紊亂甚至猝死；皮膚領(lǐng)域，它可能成為自身免疫病靶點，如天皰瘡患者免疫系統(tǒng)會錯誤攻擊該蛋白，導(dǎo)致皮膚水皰。目前藥物研發(fā)聚焦于其異常表達(dá)與疾病的關(guān)聯(lián)：針對癌癥轉(zhuǎn)移，科學(xué)家開發(fā)調(diào)節(jié)其功能的小分子或抗體藥物，阻止癌細(xì)胞脫離原發(fā)灶；心血管疾病領(lǐng)域也在探索修復(fù)其功能的療法，以期恢復(fù)心肌組織的穩(wěn)定性。
熱銷產(chǎn)品
Recombinant Human Desmoglein-2 (DSG2), partial (Active) (CSB-MP622752HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 at 2μg/mL can bind Anti-DSG2 recombinant antibody (CSB-RA622752MA1HU)， the EC50 is 20.26-38.00 ng/mL.
Recombinant Human Desmoglein-2 (DSG2), partial (CSB-EP622752HUb1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DSG2 Recombinant Monoclonal Antibody (CSB-RA622752MA1HU)
驗證數(shù)據(jù)
The Binding Activity of DSG2 with anti-DSG2 antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 (CSB-MP622752HU) at 2 μg/mL can bind Anti-DSG2 recombinant antibody，the EC50 is 20.26-38.00 ng/mL.
DSG2 Antibodies
DSG2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007204GA01HU | DSG2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007839 | DSG2 Antibody | Human | WB, ELISA |
| CSB-PA025645 | DSG2 Antibody | Human | ELISA,IHC |
| CSB-PA401715 | DSG2 Antibody | Human | ELISA,IHC |
| CSB-PA622752LA01HU | DSG2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA622752LB01HU | DSG2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA622752LC01HU | DSG2 Antibody, FITC conjugated | Human | |
| CSB-PA622752LD01HU | DSG2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA622752MA1HU | DSG2 Recombinant Monoclonal Antibody | Human | ELISA |
DSG2 Proteins
DSG2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007204MO CSB-BP007204MO CSB-MP007204MO CSB-EP007204MO-B |
Recombinant Mouse Desmoglein-2 (Dsg2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007204MO | Recombinant Mouse Desmoglein-2 (Dsg2), partial | E.coli |
DSG2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP622752HU CSB-EP622752HU CSB-EP622752HU-B |
Recombinant Human Desmoglein-2 (DSG2), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-EP622752HUb1 | Recombinant Human Desmoglein-2 (DSG2), partial | E.coli |
| CSB-BP622752HU | Recombinant Human Desmoglein-2 (DSG2), partial | Baculovirus |
| CSB-EP622752HUa0 | Recombinant Human Desmoglein-2 (DSG2), partial | E.coli |
| CSB-EP622752HUb0 | Recombinant Human Desmoglein-2 (DSG2), partial | E.coli |
| CSB-MP622752HU | Recombinant Human Desmoglein-2 (DSG2), partial (Active) | Mammalian cell |
