DSP
DSP，全稱為橋粒斑蛋白，常用別名是Desmoplakin，是構(gòu)成細胞間橋粒結(jié)構(gòu)的關(guān)鍵骨架蛋白。它主要分布在心肌、皮膚上皮等組織中，負責(zé)連接細胞骨架與細胞膜連接蛋白，讓相鄰細胞緊密結(jié)合，維持組織的機械強度和結(jié)構(gòu)完整性，對心臟和皮膚的正常結(jié)構(gòu)穩(wěn)定尤為重要。
DSP蛋白異常會引發(fā)一系列遺傳性疾病，常見的包括心肌病、皮膚角化異常、毛發(fā)稀疏等，嚴重時可導(dǎo)致心律失常性右室心肌病，增加猝死風(fēng)險。在藥物研發(fā)方面，目前以對癥支持治療為主，針對DSP相關(guān)結(jié)構(gòu)修復(fù)的基因治療和小分子干預(yù)藥物仍處在臨床前研究階段，有望為這類遺傳性皮膚心臟綜合征提供新的治療路徑。
熱銷產(chǎn)品
Recombinant Human Desmoplakin (DSP), partial (CSB-EP007208HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DSP Recombinant Monoclonal Antibody (CSB-RA241397A0HU)
驗證數(shù)據(jù)
Flow cytometric analysis of desmoplakin expression in HepG2 cells using desmoplakin antibody. Green, isotype control; red, desmoplakin.
Immunocytochemical staining of HepG2 cells with desmoplakin antibody. Nuclei were stained blue with DAPI; Desmoplakin was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
Western blotting analysis using desmoplakin antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with desmoplakin antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
DSP Antibodies
DSP for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA921679 | DSP Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA599384 | DSP Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA093388 | DSP Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA007208LA01HU | DSP Antibody | Human | ELISA |
| CSB-PA007208LC01HU | DSP Antibody, FITC conjugated | Human | |
| CSB-PA007208LD01HU | DSP Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA241397A0HU | DSP Recombinant Monoclonal Antibody | Human | ELISA, WB, FC, ICC |
| CSB-RA287633A0HU | DSP Recombinant Monoclonal Antibody | Human | ELISA, FC |
DSP Proteins
DSP Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007208HU | Recombinant Human Desmoplakin (DSP), partial | Yeast |
| CSB-EP007208HU | Recombinant Human Desmoplakin (DSP), partial | E.coli |
| CSB-BP007208HU CSB-MP007208HU CSB-EP007208HU-B |
Recombinant Human Desmoplakin (DSP), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
