F2R
F2R，全稱為凝血酶受體1，常用別名PAR-1、凝血酶受體，是一種G蛋白偶聯受體，主要表達于血小板、血管內皮細胞及多種組織細胞表面，可特異性結合凝血酶，參與凝血過程、血管收縮與修復，同時調控炎癥反應和細胞增殖，維持機體凝血與血管穩態。
F2R功能異常與多種疾病密切相關，過度激活會導致血小板異常聚集，引發血栓性疾病如心肌梗死、腦梗死，也與炎癥性疾病、動脈粥樣硬化及部分腫瘤的侵襲轉移相關。在藥物研發領域，針對F2R的拮抗劑是研究重點，部分候選藥物已進入臨床階段，通過阻斷其活性抑制血栓形成，同時在抗炎、抗腫瘤方面展現潛在價值，有望為血栓性疾病及相關病癥提供新的治療選擇。
熱銷產品
Recombinant Human Proteinase-activated receptor 1 (F2R) (CSB-CF007924HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
F2R Antibody (CSB-PA007924LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA007924LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA007924LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA007924LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
F2R Antibodies
F2R for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA212441 | F2R Antibody | Human | ELISA,WB |
| CSB-PA004289 | F2R Antibody | Human | WB, ELISA |
| CSB-PA008161 | Cleaved-F2R (S42) Antibody | Human | WB, ELISA |
| CSB-PA267410 | F2R Antibody | Human | ELISA,IHC |
| CSB-PA916397 | F2R Antibody | Human | ELISA,WB,IHC |
| CSB-PA007924LA01HU | F2R Antibody | Human | ELISA, IHC, IF |
F2R Proteins
F2R Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007924HU1 CSB-EP007924HU1 CSB-BP007924HU1 CSB-MP007924HU1 CSB-EP007924HU1-B |
Recombinant Human Proteinase-activated receptor 1 (F2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007924HU | Recombinant Human Proteinase-activated receptor 1 (F2R) | in vitro E.coli expression system |
F2R Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007924MO1 CSB-EP007924MO1 CSB-BP007924MO1 CSB-MP007924MO1 CSB-EP007924MO1-B |
Recombinant Mouse Proteinase-activated receptor 1 (F2r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007924MO | Recombinant Mouse Proteinase-activated receptor 1 (F2r) | in vitro E.coli expression system |
F2R Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007924RA1 CSB-EP007924RA1 CSB-BP007924RA1 CSB-MP007924RA1 CSB-EP007924RA1-B |
Recombinant Rat Proteinase-activated receptor 1 (F2r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007924RA | Recombinant Rat Proteinase-activated receptor 1 (F2r) | in vitro E.coli expression system |
F2R Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007924BO1 CSB-EP007924BO1 CSB-BP007924BO1 CSB-MP007924BO1 CSB-EP007924BO1-B |
Recombinant Bovine Proteinase-activated receptor 1 (F2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007924BO | Recombinant Bovine Proteinase-activated receptor 1 (F2R) | in vitro E.coli expression system |
F2R Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007924XBE1 CSB-EP007924XBE1 CSB-BP007924XBE1 CSB-MP007924XBE1 CSB-EP007924XBE1-B |
Recombinant Xenopus laevis Proteinase-activated receptor 1 (f2r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007924XBE | Recombinant Xenopus laevis Proteinase-activated receptor 1 (f2r) | in vitro E.coli expression system |
F2R Proteins for Papio hamadryas (Hamadryas baboon)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007924ERJ1 CSB-EP007924ERJ1 CSB-BP007924ERJ1 CSB-MP007924ERJ1 CSB-EP007924ERJ1-B |
Recombinant Papio hamadryas Proteinase-activated receptor 1 (F2R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007924ERJ | Recombinant Papio hamadryas Proteinase-activated receptor 1 (F2R) | in vitro E.coli expression system |
