FBXO21
FBXO21，全稱為F-box only protein 21，也被稱為F-box protein 21。該蛋白屬于F-box蛋白家族，是E3泛素連接酶復(fù)合物SCF (Skp1-Cullin-F-box)的底物識(shí)別亞基。FBXO21通過(guò)識(shí)別并連接底物蛋白，引導(dǎo)泛素化修飾，從而參與細(xì)胞內(nèi)蛋白質(zhì)的降解和調(diào)控。研究表明，F(xiàn)BXO21在急性髓系白血病細(xì)胞中能夠泛素化修飾p85α蛋白，進(jìn)而影響PI3K信號(hào)通路，調(diào)節(jié)細(xì)胞增殖和存活。此外，F(xiàn)BXO21還能泛素化修飾ASK1等蛋白，影響炎癥反應(yīng)和免疫細(xì)胞浸潤(rùn)。在腎細(xì)胞癌中，F(xiàn)BXO21的過(guò)表達(dá)能夠抑制腫瘤細(xì)胞的增殖和轉(zhuǎn)移。基于FBXO21的這些特性，研究人員正在探索其作為治療急性髓系白血病、腎細(xì)胞癌等疾病靶點(diǎn)的可能性。目前，已有針對(duì)FBXO21的抗體和重組蛋白等試劑可用于相關(guān)研究。
熱銷產(chǎn)品
FBXO21 Monoclonal Antibody (CSB-MA445423)
驗(yàn)證數(shù)據(jù)
Flow cytometric analysis of FBXO21 expression in HAP-1 cells using FBXO21 antibody. Green, isotype control; red, FBXO21.
Western blotting analysis using FBXO21 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with FBXO21 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
FBXO21 Antibodies
FBXO21 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA445423 | FBXO21 Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC |
| CSB-MA041523 | FBXO21 Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC |
FBXO21 Proteins
FBXO21 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP008488HU CSB-EP008488HU CSB-BP008488HU CSB-MP008488HU CSB-EP008488HU-B |
Recombinant Human F-box only protein 21 (FBXO21) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
