FLNB
FLNB，全稱為Filamin B，也叫β-細(xì)絲蛋白，是細(xì)胞骨架的關(guān)鍵成員之一。它能串聯(lián)細(xì)胞內(nèi)的肌動(dòng)蛋白纖維，支撐細(xì)胞形態(tài)結(jié)構(gòu)，還參與細(xì)胞移動(dòng)、分化等過程，在骨骼和結(jié)締組織發(fā)育中扮演重要角色。FLNB功能異常，可能引發(fā)多種骨骼發(fā)育疾病，比如青少年特發(fā)性脊柱側(cè)凸、胸廓畸形，以及罕見的遺傳性骨發(fā)育不全（如atelosteogenesisⅡ/Ⅲ型）、回飛鏢樣發(fā)育不良等，這些疾病多與FLNB的結(jié)構(gòu)突變相關(guān)。目前針對(duì)FLNB相關(guān)疾病的治療仍在探索階段，研究人員嘗試用小分子調(diào)節(jié)蛋白間的相互作用，或通過基因編輯修復(fù)突變位點(diǎn)，但這些策略大多處于實(shí)驗(yàn)室研究或早期臨床試驗(yàn)階段。
熱銷產(chǎn)品
Recombinant Human Filamin-B (FLNB), partial (CSB-EP008725HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FLNB Antibodies
FLNB for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008725GA01HU | FLNB Antibody | Human,Mouse,Rat | ELISA,WB,IF |
FLNB Proteins
FLNB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008725HU CSB-EP008725HU CSB-BP008725HU CSB-MP008725HU CSB-EP008725HU-B |
Recombinant Human Filamin-B (FLNB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008725HU1 | Recombinant Human Filamin-B (FLNB), partial | E.coli |
| CSB-EP008725HU1(M) | Recombinant Human Filamin-B (FLNB) (T2177A,V2354A,R2374A), partial | E.coli |
FLNB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP800356MO CSB-EP800356MO CSB-BP800356MO CSB-MP800356MO CSB-EP800356MO-B |
Recombinant Mouse Filamin-B (Flnb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FLNB Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP885623RB CSB-EP885623RB CSB-BP885623RB CSB-MP885623RB CSB-EP885623RB-B |
Recombinant Rabbit Filamin-B (FLNB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
