GAD2
GAD2，全稱為谷氨酸脫羧酶2，常用別名是GAD65，得名于其約65kDa的分子量。它在體內(nèi)的核心作用是參與合成γ-氨基丁酸（GABA）——一種能讓神經(jīng)細(xì)胞保持穩(wěn)定的物質(zhì)，避免神經(jīng)信號(hào)過度興奮。當(dāng)GAD65的功能出現(xiàn)問題時(shí)，可能打破神經(jīng)傳遞的平衡狀態(tài)。
在疾病方面，1型糖尿病患者中部分人群的免疫系統(tǒng)會(huì)錯(cuò)誤攻擊胰島β細(xì)胞上的GAD65，導(dǎo)致胰島素分泌不足；癲癇、焦慮障礙等神經(jīng)系統(tǒng)問題也常與GAD65功能紊亂相關(guān)，因?yàn)镚ABA減少會(huì)讓神經(jīng)活動(dòng)變得過于活躍。藥物研發(fā)上，針對(duì)1型糖尿病早期的GAD65疫苗正在推進(jìn)研究，希望通過調(diào)節(jié)免疫反應(yīng)保護(hù)胰島細(xì)胞；一些癲癇治療藥物也會(huì)間接促進(jìn)GAD65的活性，增加GABA水平以緩解癥狀。
熱銷產(chǎn)品
GAD2 Antibody (CSB-PA11159A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Mouse lung tissue, Mouse stomach tissue
All lanes: GAD2 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66 kDa
Observed band size: 66 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA11159A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA11159A0Rb at dilution of 1:100
Human glutamic acid decarboxylase 65,GAD65 ELISA Kit (CSB-E14119h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E14119h
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測(cè)范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
GAD2 Antibodies
GAD2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009160GA01HU | GAD2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA189687 | GAD2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA997765 | GAD2 Antibody | Human | ELISA,IHC |
| CSB-PA11159A0Rb | GAD2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA11159B0Rb | GAD2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11159C0Rb | GAD2 Antibody, FITC conjugated | Human | |
| CSB-PA11159D0Rb | GAD2 Antibody, Biotin conjugated | Human | ELISA |
GAD2 Proteins
GAD2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP1115HU CSB-EP1115HU CSB-BP1115HU CSB-MP1115HU CSB-EP1115HU-B |
Recombinant Human Glutamate decarboxylase 2 (GAD2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GAD2 ELISA Kit
GAD2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14119h | Human glutamic acid decarboxylase 65,GAD65 ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
