GJA5
GJA5，全稱為連接蛋白40，常用別名包括Cx40或Connexin-40。這種蛋白是細胞間通訊的關鍵“橋梁”，能在相鄰細胞間形成微小通道，讓小分子物質和電信號自由傳遞。在心臟組織中，它尤其重要——通過協調心肌細胞的電活動，確保心跳節奏穩定有序。
當GJA5相關的蛋白功能異常時，心臟的電信號傳導容易紊亂，可能引發房顫、室上性心動過速等心律失常問題，部分先天性心臟病如房間隔缺損也與它的異常表達有關。目前針對該蛋白的藥物研發仍在推進中，一些候選化合物試圖通過調節其通道功能來改善心律失常，已有抗心律失常藥物也可能間接影響它的作用，但專門靶向的治療藥物尚未進入臨床廣泛應用階段。
熱銷產品
Recombinant Human Gap junction alpha-5 protein (GJA5), partial (CSB-EP009448HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
GJA5 Antibody (CSB-PA009448LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA009448LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA009448LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GJA5 Antibodies
GJA5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005610 | GJA5 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA009448LA01HU | GJA5 Antibody | Human | ELISA, IHC, IF |
| CSB-PA009448LB01HU | GJA5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009448LC01HU | GJA5 Antibody, FITC conjugated | Human |
GJA5 Proteins
GJA5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP009448HU1 CSB-BP009448HU1 CSB-MP009448HU1 CSB-EP009448HU1-B |
Recombinant Human Gap junction alpha-5 protein (GJA5), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009448HU | Recombinant Human Gap junction alpha-5 protein (GJA5) | in vitro E.coli expression system |
| CSB-EP009448HU1 | Recombinant Human Gap junction alpha-5 protein (GJA5), partial | E.coli |
