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GNAQ

GNAQ,全稱為G蛋白α亞基Q,常用別名GαQ。它是細胞內G蛋白偶聯受體信號通路的關鍵組成部分,廣泛表達于人體各類組織,參與信號傳導、細胞增殖、分化及代謝調控,能夠介導多種細胞外信號向細胞內傳遞,維持機體正常生理功能。 GNAQ突變及功能異常與多種疾病密切相關,突變會導致信號通路過度激活,促進細胞異常增殖,與葡萄膜黑色素瘤、皮膚黑色素瘤等腫瘤相關;同時與遺傳性疾病、心血管疾病相關。目前GNAQ抑制劑處于臨床前及早期臨床研究階段,通過阻斷異常信號傳導,為腫瘤及遺傳性疾病提供治療方案。

熱銷產品

Recombinant Human Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) (CSB-BP342271HUn8)

驗證數據

CSB-BP342271HUn8

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GNAQ Recombinant Monoclonal Antibody (CSB-RA106255A0HU)

驗證數據

CSB-RA106255A0HU

Flow cytometric analysis of G protein subunit alpha q expression in C2C12 cells using G protein subunit alpha q antibody. Green, isotype control; red, G protein subunit alpha q.

CSB-RA106255A0HU

Immunocytochemical staining of C2C12 cells with G protein subunit alpha q antibody. Nuclei were stained blue with DAPI; G protein subunit alpha q was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

CSB-RA106255A0HU

Western blotting analysis using G protein subunit alpha q antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with G protein subunit alpha q antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

GNAQ Antibody (CSB-PA009594LA01HU)

驗證數據

CSB-PA009594LA01HU

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009594LA01HU at dilution of 1:100

CSB-PA009594LA01HU

Immunofluorescent analysis of MCF-7 cells using CSB-PA009594LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

GNAQ Antibodies

GNAQ for Homo sapiens (Human)

GNAQ Proteins

GNAQ Proteins for Rattus norvegicus (Rat)

GNAQ Proteins for Mus musculus (Mouse)

GNAQ Proteins for Xenopus laevis (African clawed frog)

GNAQ Proteins for Homo sapiens (Human)

GNAQ Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

GNAQ Proteins for Sus scrofa (Pig)



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