GPI
GPI，全稱為糖基磷脂酰肌醇，常用別名糖基磷脂酰肌醇錨定分子。它是一類特殊的細胞膜脂質錨定結構，廣泛存在于人體細胞膜表面，能夠將多種功能蛋白固定在細胞膜外側，參與細胞識別、黏附以及免疫細胞活化等生理過程，對維持細胞膜完整功能與細胞間交流十分重要。
GPI合成或錨定功能異常，會引發陣發性睡眠性血紅蛋白尿癥，同時也與自身免疫病、血液系統惡性腫瘤相關，異常表達還會增強腫瘤細胞侵襲轉移能力。目前臨床主要以對癥輸血、免疫抑制治療為主，針對GPI合成通路的靶向修復藥物及基因治療方案仍處于臨床前研究階段，有望為這類罕見血液病及相關腫瘤提供新的治療方向。
熱銷產品
PIGK Antibody (CSB-PA842143LA01HU)
驗證數據
Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate
All lanes: PIGK antibody at 2.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46, 37 kDa
Observed band size: 46 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA842143LA01HU at dilution of 1:100
GPI Antibodies
GPI for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017974GA01HU | PIGK Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA842143LA01HU | PIGK Antibody | Human | ELISA, WB, IHC |
| CSB-PA842143LB01HU | PIGK Antibody, HRP conjugated | Human | ELISA |
| CSB-PA842143LC01HU | PIGK Antibody, FITC conjugated | Human | |
| CSB-PA842143LD01HU | PIGK Antibody, Biotin conjugated | Human | ELISA |
GPI Proteins
GPI Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP842143HU CSB-EP842143HU CSB-BP842143HU CSB-MP842143HU CSB-EP842143HU-B |
Recombinant Human GPI-anchor transamidase (PIGK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
