GREM2

GREM2，全稱(chēng)為Gremlin 2，是一種分泌型糖基化蛋白，屬于BMP拮抗劑家族中的CAN亞家族。該蛋白含有保守的胱氨酸結(jié)結(jié)構(gòu)域，能夠與BMP2/4/7等配體結(jié)合，從而抑制BMP信號(hào)通路，影響細(xì)胞增殖、分化和凋亡等過(guò)程。GREM2蛋白在多種組織中表達(dá)，但在代謝相關(guān)組織中表達(dá)量較高。研究發(fā)現(xiàn)，GREM2蛋白與肥胖、糖尿病、骨質(zhì)疏松等疾病的發(fā)生發(fā)展密切相關(guān)。例如，GREM2蛋白水平與肥胖程度呈正相關(guān)，并且能夠抑制白色脂肪棕色化過(guò)程。此外，GREM2蛋白表達(dá)異常還與多種癌癥進(jìn)展相關(guān)，過(guò)表達(dá)會(huì)促進(jìn)腫瘤細(xì)胞侵襲轉(zhuǎn)移，而表達(dá)不足則可能導(dǎo)致BMP信號(hào)過(guò)度激活，影響組織穩(wěn)態(tài)。目前，針對(duì)GREM2蛋白的藥物研發(fā)正在積極進(jìn)行中，其中艾伯維/Alector的AL002和諾華的VHB937是研發(fā)進(jìn)展較快的藥物，分別處于II期和I期臨床試驗(yàn)階段，旨在治療阿爾茨海默病和癌癥等疾病。

熱銷(xiāo)產(chǎn)品

GREM2 Antibody (CSB-PA107590)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: A549 whole cell lysate(30μg),Mouse Kidney tissue lysate(30μg)
All lanes: GREM2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 20 kDa
Observed band size: 30 kDa
Exposure time: 120s

Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200

Human Gremlin-2(GREM2) ELISA kit (CSB-EL009893HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL009893HU

規(guī)格：96T/48T

靈敏度：6.25 pg/mL

檢測(cè)范圍：6.25 pg/mL-2500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

GREM2 Antibody

GREM2 Protein

GREM2 ELISA Kit

GREM2 Antibodies

GREM2 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA107590	GREM2 Antibody	Human,Mouse	WB, IHC, ELISA

GREM2 Proteins

GREM2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP887993HU CSB-EP887993HU CSB-BP887993HU CSB-MP887993HU CSB-EP887993HU-B	Recombinant Human Gremlin-2 (GREM2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli