H1-0
H1-0 蛋白全稱為H1.0 接頭組蛋白，常用別名包括 H1.0、H1F0、H1FV、H10，屬于組蛋白 H1 家族的分化亞型。它主要參與染色質(zhì)高級(jí)結(jié)構(gòu)的穩(wěn)定與壓縮，在終末分化與低增殖細(xì)胞中富集，通過(guò)約束染色質(zhì)開(kāi)放程度維持基因組轉(zhuǎn)錄穩(wěn)態(tài)，并與組蛋白去乙酰化等修飾過(guò)程協(xié)同，參與細(xì)胞狀態(tài)維持與炎癥因子表達(dá)調(diào)控。H1-0在卵巢癌等多種腫瘤中表達(dá)異常，與化療耐藥、腫瘤侵襲及炎癥網(wǎng)絡(luò)紊亂密切相關(guān)，可通過(guò)調(diào)控 IL-6 等關(guān)鍵分子影響疾病進(jìn)程。目前圍繞 H1-0 與 HDAC5 互作的靶向策略已進(jìn)入基礎(chǔ)驗(yàn)證階段，針對(duì)其表達(dá)調(diào)控與下游炎癥軸的小分子調(diào)節(jié)劑正在開(kāi)展細(xì)胞與動(dòng)物模型篩選，為耐藥腫瘤與炎癥相關(guān)疾病提供新的干預(yù)方向。
熱銷產(chǎn)品
Recombinant Human Histone H1.0 (H1-0) (CSB-EP010087HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
H1-0 Recombinant Monoclonal Antibody (CSB-RA598755A0HU)
驗(yàn)證數(shù)據(jù)
Immunocytochemical staining of C2C12 cells with Histone H1.0 antibody. Nuclei were stained blue with DAPI; Histone H1.0 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using histone H1.0 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with histone H1.0 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
H1-0 Antibodies
H1-0 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010087GA01HU | H1F0 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA010087ESR1HU | H1F0 Antibody | Human | ELISA, IHC |
| CSB-PA010087ESR2HU | H1F0 Antibody | Human | ELISA, WB, IHC |
| CSB-PA445401 | Histone 1F0 Antibody | Human | ELISA,WB |
| CSB-PA785142 | H1F0 Antibody | Human | WB, IHC, ELISA |
| CSB-PA010087PA11me1HU | Mono-methyl-H1F0 (K11) Antibody | Human | ELISA, IF |
| CSB-PA010087PA11nme1HU | H1F0 (Ab-11) Antibody | Human, Rat | ELISA, WB |
| CSB-PA010087PA107nme1HU | H1F0 (Ab-107) Antibody | Human, Rat | ELISA, WB, IF |
| CSB-PA010087OA81me1HU | Mono-methyl-H1F0 (K81) Antibody | Human | ELISA, ICC, IF, ChIP |
| CSB-PA010087OA101me1HU | Mono-methyl-H1F0 (K101) Antibody | Human | ELISA, WB, ICC, IF, ChIP |
| CSB-PA010087OA81nme1HU | H1F0 (Ab-81) Antibody | Human | ELISA, IHC, IF, ChIP |
| CSB-PA010087OA101nme1HU | H1F0 (Ab-101) Antibody | Human, Rat | ELISA, WB, IHC, IF, ChIP |
| CSB-RA010087A0HU | Histone H1.0 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-PA010087OA11me1HU | Mono-methyl-H1F0 (K11) Antibody | Human | ELISA, ICC |
| CSB-PA010087OA11nme1HU | H1F0 (Ab-11) Antibody | Human | ELISA, IHC |
| CSB-PA010087OA107me1HU | Mono-methyl-H1F0 (K107) Antibody | Human | ELISA, ICC |
| CSB-PA010087OA107nme1HU | H1F0 (Ab-107) Antibody | Human | ELISA, IHC |
| CSB-RA598755A0HU | H1-0 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, ICC |
H1-0 Proteins
H1-0 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010087HU CSB-BP010087HU CSB-MP010087HU CSB-EP010087HU-B |
Recombinant Human Histone H1.0 (H1F0) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010087HU | Recombinant Human Histone H1.0 (H1-0) | E.coli |
