HNRNPA2B1
HNRNPA2B1，全稱為異核核糖核蛋白A2/B1，常被簡稱為hnRNP A2或B1。作為細胞內重要的RNA結合蛋白，它能與多種RNA分子相互作用，參與RNA在細胞核與細胞質間的運輸，也會影響RNA的剪接和穩定性，對維持細胞正常生理活動至關重要。
HNRNPA2B1異常狀態與多種疾病存在關聯：在阿爾茨海默病患者的腦組織中，它常與異常沉積的tau蛋白結合，可能加劇神經細胞損傷；肺癌、乳腺癌等腫瘤中它的表達量明顯升高，或推動腫瘤細胞增殖與轉移；其基因突變還與肌萎縮側索硬化癥等神經退行性疾病的發生相關。目前針對它的藥物研究仍處于早期階段，部分小分子化合物被發現可干擾它與RNA的結合，有望成為相關疾病的治療候選。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of HNRNPA2B1 was greater than 95% as determined by SEC-HPLC
HNRNPA2B1 Antibody (CSB-PA010602DA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010602DA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010602DA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA010602DA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
HNRNPA2B1 Antibodies
HNRNPA2B1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010602DA01HU | HNRNPA2B1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA010602DD01HU | HNRNPA2B1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA010602GA01HU | HNRNPA2B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002943 | HNRNPA2B1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
HNRNPA2B1 Proteins
HNRNPA2B1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP2576HU | Recombinant Human Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | E.coli |
| CSB-YP2576HU | Recombinant Human Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | Yeast |
| CSB-EP2576HUa0 | Recombinant Human Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | E.coli |
| CSB-EP2576HU1 | Recombinant Human Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1), partial | E.coli |
| CSB-MP2576HU1 | Recombinant Human Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1), partial | Mammalian cell |
| CSB-YP2576HU1 | Recombinant Human Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1), partial | Yeast |
