HNRNPH2
異質(zhì)核核糖核蛋白H2（HNRNPH2）是細(xì)胞核內(nèi)一類關(guān)鍵的RNA結(jié)合蛋白，常見別名包括HNRPH2、NIFK等。它能與多種RNA分子結(jié)合，參與RNA的剪切、穩(wěn)定及胞內(nèi)轉(zhuǎn)運過程，助力RNA完成從轉(zhuǎn)錄到翻譯的關(guān)鍵步驟，對細(xì)胞生長、分化等生命活動意義重大。
臨床研究顯示，HNRNPH2異常與多種疾病相關(guān)。最典型的是Lubs型X連鎖智力障礙，患者因該蛋白功能缺陷，常表現(xiàn)出認(rèn)知發(fā)育遲緩、語言能力低下、行為異常等癥狀。此外，它在肺癌、乳腺癌等腫瘤組織中表達(dá)水平異常升高，可能促進(jìn)腫瘤細(xì)胞的增殖和轉(zhuǎn)移。目前針對HNRNPH2的藥物研發(fā)仍處于早期探索階段，科研人員正嘗試設(shè)計靶向其RNA結(jié)合區(qū)域的小分子化合物，或通過基因調(diào)控手段修正其異常表達(dá)，但尚未有進(jìn)入臨床應(yīng)用的成熟藥物。
熱銷產(chǎn)品
Recombinant Human Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) (CSB-EP346289HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Recombinant Human Heterogeneous nuclear ribonucleoprotein H2 (IL36G) (CSB-MP346289HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
HNRNPH2 Antibodies
HNRNPH2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA061816 | HNRNPH2 Antibody | Human,Mouse,Rat | ELISA,WB |
HNRNPH2 Proteins
HNRNPH2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP346289HU CSB-BP346289HU CSB-EP346289HU-B |
Recombinant Human Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP346289HU | Recombinant Human Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) | E.coli |
| CSB-MP346289HU | Recombinant Human Heterogeneous nuclear ribonucleoprotein H2 (IL36G) | Mammalian cell |
