HSD11B1
HSD11B1，即11β-羥基類固醇脫氫酶1型，也常被叫做皮質醇還原酶。它在肝臟、脂肪、大腦等組織里發揮作用，能把體內無活性的可的松轉化為有活性的皮質醇，這個過程會影響身體的糖代謝、脂肪堆積和炎癥狀態。比如在脂肪組織中，HSD11B1活性過高會讓局部皮質醇增多，促使脂肪細胞變大，可能引發肥胖和胰島素抵抗，和2型糖尿病、代謝綜合征的發生關系密切；在大腦里，它還可能參與情緒調節，和抑郁癥、焦慮癥的發病有一定聯系。
目前針對這種蛋白的抑制劑研發正在推進，部分化合物能抑制其活性，減少體內皮質醇生成，有望用于代謝性疾病的治療。不過多數候選藥物還處于臨床試驗階段，尚未正式投入臨床使用。
熱銷產品
Recombinant Human 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1), partial (CSB-EP010763HUd7)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
HSD11B1 Antibody (CSB-PA010763LA01HU)
驗證數據
Western blot
All lanes: HSD11B1 antibody at 2µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 33 kDa
Observed band size: 33 kDa
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA010763LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA010763LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
HSD11B1 Antibodies
HSD11B1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010763GA01HU | HSD11B1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA010763LA01HU | HSD11B1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA010763LB01HU | HSD11B1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010763LC01HU | HSD11B1 Antibody, FITC conjugated | Human | |
| CSB-PA010763ESR1HU | HSD11B1 Antibody | Human | ELISA, IHC |
| CSB-PA010763ESR2HU | HSD11B1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA213517 | HSD11B1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA000758 | HSD11B1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006123 | HSD11B1 Antibody | Human,Mouse,Rat | WB, ELISA |
HSD11B1 Proteins
HSD11B1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010763HU CSB-BP010763HU CSB-MP010763HU CSB-EP010763HU-B |
Recombinant Human 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010763HU | Recombinant Human 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1), partial | E.coli |
| CSB-CF010763HU | Recombinant Human Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1) | in vitro E.coli expression system |
| CSB-EP010763HUd7 | Recombinant Human 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1), partial | E.coli |
