ICA1
ICA1，全稱為胰島細胞自身抗原1，常見別名有ICA、ICAS、TMS1，是一類主要表達于胰島β細胞、腦組織及免疫細胞中的保守蛋白。它參與胰島細胞功能調控，輔助維持胰島素分泌平衡，同時在神經遞質分泌及免疫穩態調節中發揮作用，通過協同相關分子，保障機體代謝與免疫功能的正常運轉，其功能異常會打破機體相關生理平衡。
ICA1異常與多種疾病密切相關，最典型的是1型糖尿病，其相關抗體陽性是1型糖尿病自身免疫反應的重要標志，可用于疾病診斷與發病風險預測，同時也與阿爾茨海默病、自身免疫性疾病相關。目前相關研發聚焦于疾病診斷與靶向干預，診斷相關檢測試劑已廣泛應用于臨床，針對其調控網絡的靶向制劑正處于臨床前驗證階段，為相關疾病的精準診療提供了新方向。
熱銷產品
Recombinant Human Islet cell autoantigen 1 (ICA1) (CSB-EP010947HU(A4))
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ICA1 Antibody (CSB-PA12109A0Rb)
驗證數據
Western blot
All lanes: ICA1 antibody at 2µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55, 58 kDa
Observed band size: 55 kDa
Western Blot
Positive WB detected in: Mouse brain tissue
All lanes: ICA1 antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55, 58 kDa
Observed band size: 55 kDa
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA12109A0Rb at dilution of 1:50
ICA1 Antibodies
ICA1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA12109A0Rb | ICA1 Antibody | Human, Mouse | ELISA, WB, IHC |
ICA1 Proteins
ICA1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010947HU | Recombinant Human Islet cell autoantigen 1 (ICA1), partial | Yeast |
| CSB-EP010947HU | Recombinant Human Islet cell autoantigen 1 (ICA1), partial | E.coli |
| CSB-EP010947HU(F1) | Recombinant Human Islet cell autoantigen 1 (ICA1) | E.coli |
| CSB-BP010947HU CSB-MP010947HU CSB-EP010947HU-B |
Recombinant Human Islet cell autoantigen 1 (ICA1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP010947HU(F1) | Recombinant Human Islet cell autoantigen 1 (ICA1) | Yeast |
| CSB-EP010947HU(A4) | Recombinant Human Islet cell autoantigen 1 (ICA1) | E.coli |
| CSB-BP010947HU(A4) | Recombinant Human Islet cell autoantigen 1 (ICA1) | Baculovirus |
| CSB-BP010947HU(A4)d7 | Recombinant Human Islet cell autoantigen 1 (ICA1) | Baculovirus |
