IFNAR2
IFNAR2，全稱為干擾素α和β受體亞基2，是一種I型膜蛋白，與IFNAR1共同構(gòu)成干擾素α和β受體的兩條鏈。該蛋白屬于II型細(xì)胞因子受體家族，其作用機(jī)制是通過與干擾素結(jié)合，激活JAK-STAT信號(hào)通路，進(jìn)而磷酸化多種蛋白質(zhì)，包括STAT1和STAT2，從而引發(fā)一系列細(xì)胞反應(yīng)。IFNAR2在多種組織中表達(dá)，包括泌尿生殖系統(tǒng)、淋巴系統(tǒng)、肝臟和神經(jīng)系統(tǒng)。IFNAR2與乙型肝炎和免疫缺陷45相關(guān)，其突變可能導(dǎo)致免疫缺陷疾病。目前，針對(duì)IFNAR2的藥物研發(fā)主要集中在利用其作為穩(wěn)定劑來提高干擾素制劑的穩(wěn)定性和效力，例如開發(fā)長(zhǎng)效干擾素制劑。此外，IFNAR2也被用作治療自身免疫性疾病的靶點(diǎn)，例如阿斯利康的治療紅斑狼瘡新藥Saphnelo（anifrolumab）就是一種I型干擾素拮抗劑，可與IFNAR2結(jié)合，拮抗所有I型干擾素的相關(guān)活性。
熱銷產(chǎn)品
Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial (CSB-MP011047HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of IFNAR2 was greater than 95% as determined by SEC-HPLC
IFNAR2 Antibody (CSB-PA011047ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: IFNAR2 antibody at 10µg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58, 38, 28 kDa
Observed band size: 58 kDa
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA011047ESR2HU at dilution of 1:100
IFNAR2 Antibodies
IFNAR2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011047GA01HU | IFNAR2 Antibody | Human | ELISA,WB |
| CSB-PA011047ESR1HU | IFNAR2 Antibody | Human | ELISA, IHC |
| CSB-PA011047ESR2HU | IFNAR2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA11439A0Rb | IFNAR2 Antibody | Human | ELISA, IHC |
| CSB-PA11439D0Rb | IFNAR2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005590 | IFNAR2 Antibody | Human | WB, ELISA |
IFNAR2 Proteins
IFNAR2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011047HU CSB-BP011047HU CSB-EP011047HU-B |
Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP011047HU | Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial | E.coli |
| CSB-CF011047HU(A4) | Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2) | in vitro E.coli expression system |
IFNAR2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011047MO | Recombinant Mouse Interferon alpha/beta receptor 2 (Ifnar2), partial | Yeast |
| CSB-EP011047MO CSB-BP011047MO CSB-MP011047MO CSB-EP011047MO-B |
Recombinant Mouse Interferon alpha/beta receptor 2 (Ifnar2), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR2 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP850133SH CSB-EP850133SH CSB-BP850133SH CSB-MP850133SH CSB-EP850133SH-B |
Recombinant Sheep Interferon alpha/beta receptor 2 (IFNAR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856764BO CSB-EP856764BO CSB-BP856764BO CSB-MP856764BO CSB-EP856764BO-B |
Recombinant Bovine Interferon alpha/beta receptor 2 (IFNAR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR2 ELISA Kit
IFNAR2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011047HU | Human Interferon alpha/beta receptor 2(IFNAR2) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/ml |
