IL20RB
IL20RB,全稱為白細胞介素20受體β亞基,常被簡稱為IL-20Rβ,也有CRF2-8這樣的別名。它需要與IL-20受體α亞基結合形成完整的受體結構,才能接收特定細胞因子的信號,參與皮膚細胞的生長分化調控,以及腎臟等組織的炎癥反應過程。
在銀屑病患者的皮損區域,IL20RB表達水平明顯升高,與皮膚角質細胞的異常增殖和炎癥狀態密切相關;慢性腎病患者的腎臟組織中也能觀察到它的異常表達,可能推動腎損傷的進展;此外,類風濕關節炎等自身免疫疾病的發病過程里,它也扮演了一定角色。目前針對該受體的藥物研發正在推進,部分單克隆抗體已進入臨床試驗階段,比如治療中重度銀屑病的候選藥物,二期試驗結果顯示能有效減輕皮損癥狀,為相關疾病的治療提供了新方向。
熱銷產品
Recombinant Human Interleukin-20 receptor subunit beta (IL20RB), partial (CSB-MP740921HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL20RB Antibody (CSB-PA740921ESR1HU)
驗證數據
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA740921ESR1HU at dilution of 1:100
IL20RB Antibodies
IL20RB for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011632GA01HU | IL20RB Antibody | Human | ELISA,WB,IF |
| CSB-PA125791 | IL20RB Antibody | Human,Mouse | ELISA,WB |
| CSB-PA740921ESR1HU | IL20RB Antibody | Human | ELISA, IHC |
| CSB-PA740921ESR2HU | IL20RB Antibody | Human | ELISA, IHC |
| CSB-PA003026 | IL20RB Antibody | Human,Mouse | WB, IHC, ELISA |
IL20RB Proteins
IL20RB Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP740921HU CSB-EP740921HU-B |
Recombinant Human Interleukin-20 receptor subunit beta (IL20RB), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP740921HU | Recombinant Human Interleukin-20 receptor subunit beta (IL20RB), partial | E.coli |
| CSB-MP740921HU | Recombinant Human Interleukin-20 receptor subunit beta (IL20RB), partial | Mammalian cell |
| CSB-YP740921HU | Recombinant Human Interleukin-20 receptor subunit beta (IL20RB), partial | Yeast |




