JCHAIN

JCHAIN，全稱為連接鏈蛋白，常見別名有連接鏈、J鏈、Joining Chain，是一類主要由漿細(xì)胞合成的酸性糖蛋白，廣泛參與機(jī)體免疫相關(guān)生理過程。它富含半胱氨酸，可將免疫球蛋白單體連接形成二聚體或五聚體，助力分泌型免疫球蛋白A和免疫球蛋白M的組裝，同時介導(dǎo)這類抗體穿越黏膜上皮細(xì)胞，參與黏膜免疫屏障構(gòu)建，保障機(jī)體抵御病原體入侵的第一道防線功能。
JCHAIN異常與多種疾病相關(guān)，在結(jié)節(jié)性淋巴細(xì)胞為主型霍奇金淋巴瘤中常呈陽性表達(dá)，可作為疾病分型的參考指標(biāo)，其表達(dá)異常也與膠質(zhì)母細(xì)胞瘤、自身免疫性疾病及黏膜免疫功能紊亂相關(guān)。目前相關(guān)研究聚焦于其免疫調(diào)控作用的挖掘，相關(guān)檢測指標(biāo)已用于部分腫瘤的輔助診斷，針對其介導(dǎo)的抗體組裝與轉(zhuǎn)運(yùn)過程的靶向干預(yù)正處于臨床前探索階段，為免疫相關(guān)疾病及腫瘤的診療提供新思路。

熱銷產(chǎn)品

Recombinant Human Immunoglobulin J chain (JCHAIN) (CSB-EP011337HUa2)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

JCHAIN Antibody (CSB-PA011337DSR1HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA011337DSR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA011337DSR1HU at dilution of 1:100

Human Immunoglobulin J chain(IGJ) ELISA kit (CSB-E09237h)

驗(yàn)證數(shù)據(jù)

貨號：CSB-E09237h

規(guī)格：96T/48T

靈敏度：10 ng/mL

檢測范圍：10 ng/mL-40000 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

JCHAIN Antibody

JCHAIN Protein

JCHAIN ELISA Kit

JCHAIN Antibodies

JCHAIN for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA011337DSR1HU	JCHAIN Antibody	Human	ELISA, IHC

JCHAIN Proteins

JCHAIN Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-MP011337HU CSB-EP011337HU-B	Recombinant Human Immunoglobulin J chain (JCHAIN)	Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011337HU	Recombinant Human Immunoglobulin J chain (JCHAIN)	E.coli
CSB-BP011337HU	Recombinant Human Immunoglobulin J chain (JCHAIN)	Baculovirus
CSB-EP011337HUa2	Recombinant Human Immunoglobulin J chain (JCHAIN)	E.coli
CSB-EP011337HUc7	Recombinant Human Immunoglobulin J chain (JCHAIN)	E.coli
CSB-MP011337HUd9	Recombinant Human Immunoglobulin J chain (JCHAIN)	Mammalian cell