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KDR

KDR,即Kinase Domain-containing Receptor,也被稱為血管內皮生長因子受體2。KDR是一種跨膜受體酪氨酸激酶,主要在血管內皮細胞表達,參與調控血管生成和維護血管的完整性。其作用機制涉及與VEGF家族成員如VEGFA、VEGFC和VEGFD的結合,激活后引發受體二聚化和自身酪氨酸激酶活性,進而觸發下游信號通路,如PI3K-Akt、Ras-Raf-MEK-ERK等,這些通路促進內皮細胞的增殖、遷移和血管通透性的增加。KDR在胚胎發育、組織修復、傷口愈合中發揮關鍵作用,是正常生理功能中必不可少的。同時,KDR的功能在多種病理狀態下也至關重要,尤其是在腫瘤血管生成中,其過度激活與多種腫瘤的進展、轉移密切相關,使其成為癌癥治療的重要靶點。此外,KDR還在某些心血管疾病中發揮作用,是研究和治療相關疾病的潛在靶點。

熱銷產品

Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial (Active) (CSB-MP012145HU)

驗證數據

CSB-MP012145HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012145HU

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human VEGFA(CSB-MP025833HU(F4)) at 2 μg/ml can bind Human KDR. The EC50 is 11.19-12.63 ng/mL.

CSB-MP012145HU

The purity of KDR was greater than 90% as determined by SEC-HPLC

Recombinant Mouse Vascular endothelial growth factor receptor 2 (Kdr), partial (Active) (CSB-MP012145MO)

驗證數據

CSB-MP012145MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012145MO

Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse Vegfa (CSB-MP7360MO) at 2 μg/ml can bind Mouse Kdr. The EC50 is 12.64-13.88 ng/mL.

CSB-MP012145MO

Activity
Recombinant Mouse Kdr captured on Protein A Chip can bind Recombinant Mouse Vegfa (CSB-MP7360MO) with an affinity constant of 3.24 nM as detected by MetaSPR Assay (WeSPRTM 200).

CSB-MP012145MO

The purity of Kdr was greater than 95% as determined by SEC-HPLC

Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial (CSB-EP012145HU)

驗證數據

CSB-EP012145HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KDR Antibody (CSB-PA07279A0Rb)

驗證數據

CSB-PA07279A0Rb

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA07279A0Rb at dilution of 1:100

CSB-PA07279A0Rb

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA07279A0Rb at dilution of 1:100

KDR Antibodies

KDR for Homo sapiens (Human)

KDR Proteins

KDR Proteins for Mus musculus (Mouse)

KDR Proteins for Homo sapiens (Human)

KDR Proteins for Rattus norvegicus (Rat)

KDR Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

KDR Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

KDR ELISA Kit

KDR ELISA Kit for Homo sapiens (Human)

KDR ELISA Kit for Mus musculus (Mouse)

KDR ELISA Kit for Rattus norvegicus (Rat)



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