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KIR2DL3

KIR2DL3,全稱殺傷細胞免疫球蛋白樣受體2DL3,是一種存在于自然殺傷細胞表面的蛋白,屬于免疫球蛋白超家族。該蛋白常見別名為CD158b2、NKAT-2等,主要通過與HLA-C等位基因(如HLA-Cw1、HLA-Cw3和HLA-Cw7)相互作用,抑制NK細胞的活性,從而阻止細胞裂解。KIR2DL3在免疫調節中扮演重要角色,其表達的多態性與多種疾病相關,包括癌癥和自身免疫性疾病。近年來,針對KIR2DL3的藥物研發取得了一定進展,例如有抗體藥物可阻斷KIR2DL1-3,提高AML急變期的NK細胞毒性和ADCC反應。此外,也有針對KIR3DL2的藥物在研發中,主要應用于腫瘤和自身免疫性疾病治療。KIR2DL3相關的研究為免疫治療提供了新的思路,未來有望在疾病診斷和治療中發揮更大作用。

熱銷產品

Recombinant Human Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3), partial (Active) (CSB-MP012354HU)

驗證數據

CSB-MP012354HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012354HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human KIR2DL3 at 2 μg/ml can bind Anti-KIR2DL3 recombinant antibody (CSB-RA012352MA1HU). The EC50 is 7.203-8.603 ng/mL.

CSB-MP012354HU

Activity
KIR2DL3 Recombinant Monoclonal Antibody (CSB-RA012352MA1HU) captured on Protein A Chip can bind Recombinant Human KIR2DL3 with an affinity constant of 0.67 nM as detected by MetaSPR Assay (WeSPRTM 200).

CSB-MP012354HU

The purity of KIR2DL3 was greater than 90% as determined by SEC-HPLC

KIR2DL3 Antibody (CSB-PA012354LA01HU)

驗證數據

CSB-PA012354LA01HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA012354LA01HU at dilution of 1:100

CSB-PA012354LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA012354LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

KIR2DL3 Antibodies

KIR2DL3 for Homo sapiens (Human)

KIR2DL3 Proteins

KIR2DL3 Proteins for Homo sapiens (Human)



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