KMO
KMO，全稱為犬尿氨酸 3 - 單加氧酶，也叫犬尿氨酸 3 - 羥化酶，是定位于線粒體外膜的黃素蛋白，核心參與色氨酸分解代謝，將犬尿氨酸轉化為 3 - 羥基犬尿氨酸，調控神經活性物質與炎癥介質生成，維持神經、免疫穩態。
KMO功能異常與多種疾病緊密關聯，在亨廷頓病、帕金森病、阿爾茨海默病等神經退行性疾病中，會促使神經毒性物質累積加劇損傷。同時也與精神分裂癥、類風濕關節炎、非酒精性脂肪肝及部分腫瘤相關。目前，RO 61-8048、GSK180 等小分子抑制劑已進入臨床前研究，通過抑制其活性調節代謝平衡，為相關疾病提供新的治療方向。
熱銷產品
Recombinant Human Kynurenine 3-monooxygenase (KMO) (CSB-EP012475HUa0)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KMO Antibody (CSB-PA012475LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA012475LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA012475LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
KMO Antibodies
KMO for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012475GA01HU | KMO Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA012475LA01HU | KMO Antibody | Human | ELISA, IHC, IF |
| CSB-PA012475LC01HU | KMO Antibody, FITC conjugated | Human | |
| CSB-PA012475ESR1HU | KMO Antibody | Human, Mouse | ELISA, WB, IHC |
KMO Proteins
KMO Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012475HU | Recombinant Human Kynurenine 3-monooxygenase (KMO) | Yeast |
| CSB-EP012475HU | Recombinant Human Kynurenine 3-monooxygenase (KMO) | E.coli |
| CSB-CF012475HU | Recombinant Human Kynurenine 3-monooxygenase (KMO) | in vitro E.coli expression system |
| CSB-EP012475HUa0 | Recombinant Human Kynurenine 3-monooxygenase (KMO) | E.coli |
| CSB-EP012475HUb0 | Recombinant Human Kynurenine 3-monooxygenase (KMO) | E.coli |
