LRP3
LRP3，全稱(chēng)為低密度脂蛋白受體相關(guān)蛋白3，常用別名LRP3蛋白。它是細(xì)胞膜上的低密度脂蛋白受體家族成員，廣泛表達(dá)于人體各類(lèi)組織，參與脂質(zhì)轉(zhuǎn)運(yùn)、信號(hào)傳導(dǎo)及細(xì)胞黏附調(diào)控，對(duì)脂質(zhì)穩(wěn)態(tài)、組織發(fā)育及腫瘤進(jìn)展具有重要作用，同時(shí)參與Wnt信號(hào)通路調(diào)控。 LRP3異常表達(dá)與脂質(zhì)代謝紊亂及腫瘤密切相關(guān)，表達(dá)不足會(huì)導(dǎo)致脂質(zhì)轉(zhuǎn)運(yùn)異常，與高脂血癥、動(dòng)脈粥樣硬化相關(guān)；異常高表達(dá)則與肺癌、肝癌、骨肉瘤等腫瘤相關(guān)，促進(jìn)腫瘤細(xì)胞增殖、侵襲轉(zhuǎn)移。目前LRP3抑制劑處于臨床前研究階段，通過(guò)調(diào)控其脂質(zhì)轉(zhuǎn)運(yùn)及信號(hào)傳導(dǎo)功能，為脂質(zhì)代謝疾病及腫瘤提供治療方案。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts from RAW264.7 cells, using LRP3 antibody.
LRP3 Antibodies
LRP3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA086515 | LRP3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009878 | LRP3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA288262 | LRP3 Antibody | Human | ELISA,IHC |
LRP3 Proteins
LRP3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP013098HU1 CSB-EP013098HU1 CSB-BP013098HU1 CSB-MP013098HU1 CSB-EP013098HU1-B |
Recombinant Human Low-density lipoprotein receptor-related protein 3 (LRP3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013098HU | Recombinant Human Low-density lipoprotein receptor-related protein 3 (LRP3) | in vitro E.coli expression system |
