MACROD1
MACROD1，全稱為Macro domain蛋白1，它是細胞內具有去ADP核糖基化活性的蛋白，廣泛表達于人體各類組織，參與蛋白質去ADP核糖基化修飾、DNA損傷修復、細胞應激應答調控，維持細胞內蛋白穩態與基因組穩定。 MACROD1表達異常與多種疾病密切相關，功能缺陷會導致DNA損傷修復異常、應激應答障礙，與神經退行性疾病、腫瘤相關；異常表達則會促進腫瘤細胞增殖、耐藥，提示患者預后不良。目前MACROD1抑制劑處于臨床前研究階段，通過調控其去ADP核糖基化活性，為腫瘤及神經退行性疾病提供潛在治療方案。
熱銷產品
Recombinant Human ADP-ribose glycohydrolase MACROD1 (MACROD1) (CSB-BP860244HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MACROD1 Antibody (CSB-PA860244LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA860244LA01HU at dilution of 1:100
MACROD1 Antibodies
MACROD1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA860244LA01HU | MACROD1 Antibody | Human | ELISA, IHC |
| CSB-PA860244LD01HU | MACROD1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA860244LC01HU | MACROD1 Antibody, FITC conjugated | Human | |
| CSB-PA860244LB01HU | MACROD1 Antibody, HRP conjugated | Human | ELISA |
MACROD1 Proteins
MACROD1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP860244HU CSB-MP860244HU CSB-EP860244HU-B |
Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 (MACROD1) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP860244HU | Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 (MACROD1) | E.coli |
| CSB-BP860244HU | Recombinant Human ADP-ribose glycohydrolase MACROD1 (MACROD1) | Baculovirus |
