MAGEA2
MAGEA2，全稱為黑色素瘤相關抗原A2，常被簡稱為MAGE-2。它是一種腫瘤相關抗原，在黑色素瘤、非小細胞肺癌、乳腺癌等多種惡性腫瘤細胞中大量表達，但在正常人體組織里，僅在睪丸、胎盤這類免疫豁免區域有少量存在，這一特性讓它成為腫瘤免疫治療的熱門靶點。
MAGEA2會參與腫瘤細胞的生長調控，幫助腫瘤細胞逃避免疫系統的識別和攻擊。臨床研究發現，MAGEA2高表達的腫瘤患者往往預后較差。目前針對它的藥物研發主要集中在免疫治療領域，比如基于其抗原肽的腫瘤疫苗已進入臨床試驗階段，通過刺激機體產生特異性免疫細胞來清除腫瘤；靶向MAGEA2的CAR-T細胞療法也在探索中，不過這些療法仍處于優化階段，尚未正式應用于臨床治療。
熱銷產品
Recombinant Human Melanoma-associated antigen 2 (MAGEA2) (CSB-EP013327HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MAGEA2 Antibody (CSB-PA013327LA01HU)
驗證數據
Western Blot
Positive WB detected in: K562 whole cell lysate, Raji whole cell lysate
All lanes: MAGEA2 antibody at 4.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36 kDa
Observed band size: 36 kDa
MAGEA2 Antibodies
MAGEA2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA187447 | MAGEA2 Antibody | Human | ELISA,WB |
| CSB-PA116739 | MAGEA2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA013327LA01HU | MAGEA2 Antibody | Human | ELISA, WB |
| CSB-PA013327LC01HU | MAGEA2 Antibody, FITC conjugated | Human | |
| CSB-PA013327LD01HU | MAGEA2 Antibody, Biotin conjugated | Human | ELISA |
MAGEA2 Proteins
MAGEA2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013327HU CSB-BP013327HU CSB-EP013327HU-B |
Recombinant Human Melanoma-associated antigen 2 (MAGEA2) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP013327HU | Recombinant Human Melanoma-associated antigen 2 (MAGEA2) | E.coli |
| CSB-MP013327HU | Recombinant Human Melanoma-associated antigen 2 (MAGEA2; MAGEA2B) | Mammalian cell |
