MAN1A2
MAN1A2，全稱為α-1,2-甘露糖苷酶1A2，常被簡稱為甘露糖苷酶1A2。它主要存在于細胞內的高爾基體中，參與蛋白質的糖鏈修飾過程——具體來說，就是修剪新生糖蛋白上的甘露糖殘基，幫助這些蛋白正確折疊并運輸到合適的位置，從而維持細胞的正常生理功能。
當MAN1A2功能出現異常時，可能導致糖蛋白加工紊亂，進而引發多種問題。比如在一些先天性代謝疾病中，患者體內該蛋白活性不足，會影響多種糖蛋白的功能，出現發育遲緩、器官功能異常等癥狀。此外，部分腫瘤組織中該蛋白的表達水平發生改變，可能與腫瘤細胞的生長和轉移有關。目前針對該蛋白的藥物研發仍處于早期階段，研究人員正探索相關抑制劑，希望通過調節其活性來干預疾病進展，但尚未有成熟藥物進入臨床應用。
熱銷產品
MAN2A1 Antibody (CSB-PA613697LA01HU)
驗證數據
Western Blot
Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate
All lanes: MAN2A1 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 132 kDa
Observed band size: 150 kDa
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613697LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA613697LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA613697LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MAN1A2 Antibodies
MAN1A2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA013384GA01HU | MAN1A2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA613697LA01HU | MAN2A1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA613697LB01HU | MAN2A1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA613697LC01HU | MAN2A1 Antibody, FITC conjugated | Human | |
| CSB-PA613697LD01HU | MAN2A1 Antibody, Biotin conjugated | Human | ELISA |
MAN1A2 Proteins
MAN1A2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013384MO1 CSB-EP013384MO1 CSB-BP013384MO1 CSB-MP013384MO1 CSB-EP013384MO1-B |
Recombinant Mouse Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (Man1a2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013384MO | Recombinant Mouse Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (Man1a2) | in vitro E.coli expression system |
MAN1A2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013384HU1 CSB-EP013384HU1 CSB-BP013384HU1 CSB-MP013384HU1 CSB-EP013384HU1-B |
Recombinant Human Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP613697HU CSB-EP613697HU CSB-BP613697HU CSB-MP613697HU CSB-EP613697HU-B |
Recombinant Human Alpha-mannosidase 2 (MAN2A1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013384HU | Recombinant Human Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) | in vitro E.coli expression system |
| CSB-MP013384HU | Recombinant Human Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2)-VLPs | Mammalian cell |
