MIA
黑色素瘤抑制性活性蛋白（Melanoma inhibitory activity，MIA）又稱MIA1或CD-RAP，最初在黑色素瘤細(xì)胞中發(fā)現(xiàn)，屬于分泌型胞外基質(zhì)蛋白家族。MIA通過結(jié)合細(xì)胞表面整合素受體（如α4β1、α5β1）干擾細(xì)胞與基質(zhì)的黏附，同時(shí)激活ERK/MAPK信號(hào)通路，促進(jìn)腫瘤細(xì)胞侵襲轉(zhuǎn)移。MIA在黑色素瘤、乳腺癌、肝癌等多種惡性腫瘤中高表達(dá)，其水平與腫瘤分期、轉(zhuǎn)移風(fēng)險(xiǎn)正相關(guān)，可作為預(yù)后標(biāo)志物。近年來，針對(duì)MIA的靶向治療策略逐漸興起，德國團(tuán)隊(duì)開發(fā)的MIA抗體已進(jìn)入臨床前研究，能有效抑制黑色素瘤細(xì)胞遷移。小分子抑制劑如PD98059通過阻斷MIA下游信號(hào)通路顯示出抗腫瘤潛力。非癌性疾病中，MIA還參與軟骨發(fā)育調(diào)控，其基因突變與骨骼發(fā)育異常相關(guān)。
熱銷產(chǎn)品
MIA Antibody (CSB-PA613694LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA613694LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA613694LA01HU at dilution of 1:100
MIA Antibodies
MIA for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA759156 | MIA Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA060224 | MIA Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA283943 | MIA Antibody | Human | IHC,ELISA |
| CSB-PA613694LA01HU | MIA Antibody | Human | ELISA, IHC |
| CSB-PA613694LB01HU | MIA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA613694LC01HU | MIA Antibody, FITC conjugated | Human |
MIA Proteins
MIA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP613694HU CSB-EP613694HU CSB-BP613694HU CSB-MP613694HU CSB-EP613694HU-B |
Recombinant Human Melanoma-derived growth regulatory protein (MIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP000431HU | Recombinant Human Melanoma-derived growth regulatory protein (MIA) | E.Coli |
MIA Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP631694BO CSB-EP631694BO CSB-BP631694BO CSB-MP631694BO CSB-EP631694BO-B |
Recombinant Bovine Melanoma-derived growth regulatory protein (MIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MIA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP720265MO CSB-EP720265MO CSB-BP720265MO CSB-MP720265MO CSB-EP720265MO-B |
Recombinant Mouse Melanoma-derived growth regulatory protein (Mia) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MIA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP737099RA CSB-EP737099RA CSB-BP737099RA CSB-MP737099RA CSB-EP737099RA-B |
Recombinant Rat Melanoma-derived growth regulatory protein (Mia) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MIA ELISA Kit
MIA ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL013798MO | Mouse Melanoma-derived growth regulatory protein(MIA) ELISA kit | serum, plasma, tissue homogenates | 1.17 pg/mL |
