MLKL
MLKL，全稱為混合譜系激酶結(jié)構(gòu)域樣蛋白，它沒有特別廣泛使用的別名，通常直接以MLKL或全名指代，是參與細(xì)胞死亡調(diào)控的重要分子。當(dāng)細(xì)胞受到特定刺激時，MLKL會被激活，隨后通過改變自身結(jié)構(gòu)插入細(xì)胞膜，破壞膜的完整性，最終導(dǎo)致細(xì)胞壞死。這種細(xì)胞死亡方式常與炎癥反應(yīng)相伴，若MLKL活性異常，可能引發(fā)多種炎癥相關(guān)疾病——比如潰瘍性結(jié)腸炎患者的腸道病變組織中，MLKL的表達(dá)水平往往顯著升高；類風(fēng)濕關(guān)節(jié)炎等自身免疫病中，它也可能參與炎癥的持續(xù)放大。目前，針對MLKL的藥物研發(fā)正逐步推進(jìn)，一些小分子抑制劑已進(jìn)入早期試驗階段，這些藥物試圖通過抑制MLKL的活性來減輕過度炎癥，為治療上述疾病提供新的潛在方案。
熱銷產(chǎn)品
Recombinant Human Mixed lineage kinase domain-like protein (MLKL) (CSB-EP850851HUb2)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MLKL Recombinant Monoclonal Antibody (CSB-RA208170A0HU)
驗證數(shù)據(jù)
Flow cytometric analysis of MLKL expression in HepG2 cells using MLKL antibody. Green, isotype control; red, MLKL.
Immunocytochemical staining of HepG2 cells with MLKL antibody. Nuclei were stained blue with DAPI; MLKL was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using MLKL antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with MLKL antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
MLKL Antibodies
MLKL for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA850851LA01HU | MLKL Antibody | Human | ELISA, IHC |
| CSB-PA850851LC01HU | MLKL Antibody, FITC conjugated | Human | |
| CSB-PA003250 | MLKL Antibody | Human | WB, ELISA |
| CSB-RA850851A358phHU | Phospho-MLKL (S358) Recombinant Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA208170A0HU | MLKL Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
| CSB-RA087218A0HU | MLKL Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, FC |
| CSB-RA998971A0HU | MLKL Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, FC |
MLKL Proteins
MLKL Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP850851HU | Recombinant Human Mixed lineage kinase domain-like protein (MLKL) | Yeast |
| CSB-EP850851HU | Recombinant Human Mixed lineage kinase domain-like protein (MLKL) | E.coli |
| CSB-BP850851HU CSB-MP850851HU CSB-EP850851HU-B |
Recombinant Human Mixed lineage kinase domain-like protein (MLKL) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP850851HUb2 | Recombinant Human Mixed lineage kinase domain-like protein (MLKL) | E.coli |
MLKL Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP861529MO | Recombinant Mouse Mixed lineage kinase domain-like protein (Mlkl) | Yeast |
| CSB-EP861529MO CSB-BP861529MO CSB-MP861529MO CSB-EP861529MO-B |
Recombinant Mouse Mixed lineage kinase domain-like protein (Mlkl) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLKL Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP850851HUa0 | Recombinant Human Mixed lineage kinase domain-like protein (MLKL) | E.coli |
