MOV10
MOV10，全稱為莫洛尼白血病病毒10同源物，常用別名包括MOV10p或RNA解旋酶MOV10。它能解開RNA分子的雙鏈結構，在細胞內參與多種RNA相關的生理過程：比如維持mRNA的正常代謝，調控蛋白質合成的效率，還能與病毒RNA結合影響其復制。
在疾病方面，MOV10和HIV感染關系緊密——通過結合HIV的RNA鏈，它能抑制病毒在細胞內的增殖；在乳腺癌、肺癌等腫瘤中，它的表達水平常出現異常，可能影響腫瘤細胞的生長速度和轉移能力；此外，它也被發現與某些神經退行性疾病相關，可能和病變中RNA的異常聚集有關。目前針對MOV10的藥物研發尚處于早期探索階段，研究人員正嘗試尋找能調節其活性的小分子，希望通過增強它的抗病毒能力來對抗HIV，或通過糾正其在腫瘤中的異常表達來抑制癌細胞生長。
熱銷產品
Recombinant Human helicase MOV-10 (MOV10) (CSB-EP862068HU(A4))
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MOV10 Recombinant Monoclonal Antibody (CSB-RA829165A0HU)
驗證數據
Flow cytometric analysis of MOV10 expression in HeLa cells using MOV10 antibody. Green, isotype control; red, MOV10.
Immunocytochemical staining of HeLa cells with MOV10 antibody. Nuclei were stained blue with DAPI; MOV10 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using MOV10 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with MOV10 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
MOV10 Antibody (CSB-PA862068LA01HU)
驗證數據
Western blot
All lanes: MOV10 antibody at 0.4µg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 114, 102, 7 kDa
Observed band size: 114 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA862068LA01HU at dilution of 1:100
MOV10 Antibodies
MOV10 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA014739GA01HU | MOV10 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA862068LA01HU | MOV10 Antibody | Human | ELISA, WB, IHC |
| CSB-PA862068LB01HU | MOV10 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA862068LC01HU | MOV10 Antibody, FITC conjugated | Human | |
| CSB-PA862068LD01HU | MOV10 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA829165A0HU | MOV10 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
MOV10 Proteins
MOV10 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP014739MO CSB-EP014739MO CSB-BP014739MO CSB-MP014739MO CSB-EP014739MO-B |
Recombinant Mouse Putative helicase MOV-10 (Mov10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MOV10 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP607138BO CSB-EP607138BO CSB-BP607138BO CSB-MP607138BO CSB-EP607138BO-B |
Recombinant Bovine Putative helicase MOV-10 (MOV10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MOV10 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP713739CH CSB-EP713739CH CSB-BP713739CH CSB-MP713739CH CSB-EP713739CH-B |
Recombinant Chicken Putative helicase MOV-10 (MOV10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MOV10 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP862068HU CSB-EP862068HU CSB-BP862068HU CSB-MP862068HU CSB-EP862068HU-B |
Recombinant Human Putative helicase MOV-10 (MOV10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP862068HU(A4) | Recombinant Human helicase MOV-10 (MOV10) | E.coli |
