ORC1
ORC1，全稱為起始識別復合物亞基1，常見別名包括ORC-1、HSORC1等。它是細胞內調控DNA復制起始的核心蛋白之一，在細胞周期的特定階段發揮作用，能與Cdc6等蛋白協作，和其他亞基組裝成復合物，精準識別DNA上的復制起點，推動復制過程啟動，對維持基因組穩定和細胞正常增殖意義重大。在多種疾病中，ORC1的表達或功能出現異常：比如部分胃癌、肺癌患者的腫瘤組織中，ORC1水平明顯升高，可能助力腫瘤細胞不受控分裂；一些遺傳性疾病也與它的功能缺陷相關。目前針對ORC1的藥物研發處于探索階段，研究人員正嘗試開發能抑制其活性的小分子化合物，通過干擾異常的DNA復制來遏制腫瘤生長，但相關藥物尚未進入臨床應用階段。
熱銷產品
Recombinant Human Origin recognition complex subunit 1 (ORC1) (CSB-EP621667HU(A4))
驗證數據
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數據
Western Blot analysis of 3T3 cells using ORC1 Polyclonal Antibody
Western Blot analysis of NIH-3T3 HELA 293 cells using ORC1 Polyclonal Antibody
ORC1 Antibodies
ORC1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA003602 | ORC1 Antibody | Human | WB, ELISA |
ORC1 Proteins
ORC1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017231KBK CSB-EP017231KBK CSB-BP017231KBK CSB-MP017231KBK CSB-EP017231KBK-B |
Recombinant Kluyveromyces lactis Origin recognition complex subunit 1 (ORC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017231SVG CSB-EP017231SVG CSB-BP017231SVG CSB-MP017231SVG CSB-EP017231SVG-B |
Recombinant Saccharomyces cerevisiae Origin recognition complex subunit 1 (ORC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017231SXV CSB-EP017231SXV CSB-BP017231SXV CSB-MP017231SXV CSB-EP017231SXV-B |
Recombinant Schizosaccharomyces pombe Origin recognition complex subunit 1 (orc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017231DLU CSB-EP017231DLU CSB-BP017231DLU CSB-MP017231DLU CSB-EP017231DLU-B |
Recombinant Drosophila melanogaster Origin recognition complex subunit 1 (Orc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Candida albicans (Yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017231CZF CSB-EP017231CZF CSB-BP017231CZF CSB-MP017231CZF CSB-EP017231CZF-B |
Recombinant Candida albicans Origin recognition complex subunit 1 (ORC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Homo sapiens (Human)
ORC1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP691303BO CSB-EP691303BO CSB-BP691303BO CSB-MP691303BO CSB-EP691303BO-B |
Recombinant Bovine Origin recognition complex subunit 1 (ORC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP715359DIS CSB-EP715359DIS CSB-BP715359DIS CSB-MP715359DIS CSB-EP715359DIS-B |
Recombinant Debaryomyces hansenii Origin recognition complex subunit 1 (ORC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP800370RA CSB-EP800370RA CSB-BP800370RA CSB-MP800370RA CSB-EP800370RA-B |
Recombinant Rat Origin recognition complex subunit 1 (Orc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Plasmodium falciparum (isolate 3D7)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP815516EWP CSB-EP815516EWP CSB-BP815516EWP CSB-MP815516EWP CSB-EP815516EWP-B |
Recombinant Plasmodium falciparum Origin recognition complex subunit 1 (orc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP884911DXU CSB-EP884911DXU CSB-BP884911DXU CSB-MP884911DXU CSB-EP884911DXU-B |
Recombinant Cricetulus griseus Origin recognition complex subunit 1 (ORC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ORC1 Proteins for Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP897395AYB CSB-EP897395AYB CSB-BP897395AYB CSB-MP897395AYB CSB-EP897395AYB-B |
Recombinant Aeropyrum pernix Cell division control protein 6 homolog (cdc6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
