PCLAF
PCLAF，全稱為PCNA鉗夾相關(guān)因子，是一種在細(xì)胞生物合成過(guò)程中發(fā)揮重要作用的蛋白質(zhì)。它常見于多種癌癥中，且表達(dá)水平與預(yù)后不良顯著相關(guān)。研究表明，PCLAF的表達(dá)與活化的CD4 T細(xì)胞和2型輔助T細(xì)胞呈正相關(guān)，提示其在腫瘤免疫浸潤(rùn)中可能發(fā)揮特定作用。此外，PCLAF還涉及有絲分裂細(xì)胞周期過(guò)程、細(xì)胞分裂和DNA復(fù)制等關(guān)鍵生物過(guò)程。在藥物研發(fā)方面，貴州醫(yī)科大學(xué)何彬團(tuán)隊(duì)發(fā)現(xiàn)青蒿素衍生的PROTAC可以促進(jìn)PCLAF的降解，從而抑制腫瘤細(xì)胞增殖并誘導(dǎo)細(xì)胞凋亡，為血液瘤的治療提供了新的思路。這一發(fā)現(xiàn)不僅揭示了PCLAF在腫瘤發(fā)生發(fā)展中的重要作用，也為開發(fā)針對(duì)PCLAF的靶向藥物提供了新的方向。
熱銷產(chǎn)品
Recombinant Human PCNA-associated factor (PCLAF) (CSB-EP012164HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PCLAF Antibodies
PCLAF for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012164DD01HU | PCLAF Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA012164DC01HU | PCLAF Antibody, FITC conjugated | Human | |
| CSB-PA012164DB01HU | PCLAF Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012164DA01HU | PCLAF Antibody | Human | ELISA |
PCLAF Proteins
PCLAF Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP619957HU CSB-EP619957HU CSB-BP619957HU CSB-MP619957HU CSB-EP619957HU-B |
Recombinant Human PCNA-associated factor (PAF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012164HU | Recombinant Human PCNA-associated factor (PCLAF) | E.coli |
PCLAF Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP704829BO CSB-EP704829BO CSB-BP704829BO CSB-MP704829BO CSB-EP704829BO-B |
Recombinant Bovine PCNA-associated factor (PAF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCLAF Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP740849RA CSB-EP740849RA CSB-BP740849RA CSB-MP740849RA CSB-EP740849RA-B |
Recombinant Rat PCNA-associated factor (Paf) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCLAF Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP866595MO CSB-EP866595MO CSB-BP866595MO CSB-MP866595MO CSB-EP866595MO-B |
Recombinant Mouse PCNA-associated factor (Paf) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
